The [3 + 2] cycloaddition reaction of 2-arylthiocarbamoyl benzimidazolium, -imidazolinium, and -triazolium inner salts (the ambident C-C-N and C-C-S 1,3-dipoles derived from carbenes) with ketenes proceeded efficiently in a highly site-selective manner to produce the C-C-N cycloaddition products benzimidazoline-, imidazolidine-, or triazoline spiro-pyrrolidones in 58-93% yields. Theoretical cal...

In the course of our continuing efforts to identify bioactive secondary metabolites from Red Sea marine invertebrates, we have investigated the sponge Hemimycale arabica. The antimicrobial fraction of an organic extract of the sponge afforded two new hydantoin alkaloids, hemimycalins A and B (2 and 3), together with the previously reported compound (Z)-5-(4-hydroxybenzylidene)imidazolidine-2,4-...

The title compound, C(25)H(30)N(2)O(6), has the imidazolidine ring in an envelope conformation. There are two intra-molecular O-H⋯N hydrogen-bond inter-actions with graph-set motif S(6). The cyclo-hexane ring adopts a slightly distorted chair conformation. One methyl carboxyl-ate substituent forms a dihedral angle of 12.00 (5)° with the plane of the benzene ring, while the other methyl carboxyl...

In the title compound, C25H36N2O2, the two tert-butyl-substituted benzene rings are inclined at an angle of 53.5 (3)° to one another. The imidazolidine ring has an envelope conformation with with one of the C atoms of the ethylene fragment as the flap. The structure displays two intra-molecular O-H⋯N hydrogen bonds that generate S(6) ring motifs. The crystal studied was a non-merohedral twin wi...

In the title compound, C(6)H(11)N(3)O(3), the imidazolidine NH group is involved in a three-center N-H⋯O hydrogen bond, with intra-molecular and inter-molecular branches, to the nitro group O atoms. The centrosymmetric dimers that are formed are further connected by O-H⋯O hydrogen bonds between the hy-droxy and nitro groups into a two-dimensional polymeric structure extending parallel to (101).

4-(imidazoyl-1-yl)butanamide derivatives as antimuscarinic activity agents were reported by the Kyorin Discovery Research group. Among them, 4-(2-methyl-1H-imidazol1-yl)-2,2-diphenylbutanamide [KRP-197/ONO-8025, 1] is under clinical evaluation as a new type of treatment for urinary incontinence with highly subtype receptor selective antimuscarinic activity. During the course of the metabolite s...

This study included synthesis of new serotonin derivatives in which imidazolidine rings are present their structures. The final compounds were synthesized by reaction synthesized
 
 Schiff bases with the glycine (NH2-CH2COOH) presence tetrahydrofuran (THF) as a solvent. identified physical characteristics, FT-IR spectroscopy and 1H- NMR spectroscopy. Biological activities against two ...