In the title Schiff base, C(16)H(16)ClNO(2), the 2-(4-methoxy-phen-yl)ethyl (CH(3)OC(6)H(4)CH(2)CH(2)-; r.m.s. deviation = 0.10 Å) and 4-chloro-2-(imino-meth-yl)phenol (N=CHC(6)H(3)ClOH; r.m.s. deviation = 0.01 Å) portions are both essentially planar, the two parts being inclined at an angle of 61.8 (1)°. The hydroxy group forms a hydrogen bond to the imino N atom.

The title compound, [Ni(C4H8N3)2]·CH3OH, contains two independent Ni(II) atoms, each located on an inversion center and coordinated by four N atoms from two 1-[(1-imino-eth-yl)imino]-eth-yl}aza-nide ligands in a square-planar geometry. N-H⋯N, N-H⋯O and O-H⋯N hydrogen bonds link the complex mol-ecules and methanol solvent mol-ecules into a corrugated layer parallel to (001).

The N-alkyl moiety of N-alkylated imino sugars is crucial for therapeutic activities of these compounds as inhibitors of glycosphingolipid (GSL) biosynthesis and as antivirals. The improved potency afforded by a long N-alkyl moiety is coincident with increased compound-induced cytotoxicity. Therefore, in the present study, we examined the mechanism of this cytotoxicity in detail. Despite N-buty...

The discovery of salutary effects of low doses of carbon monoxide (CO) has spurred interest in designing exogenous molecules that can deliver CO to biological targets under controlled conditions. Herein we report a water-soluble photosensitive manganese carbonyl complex [MnBr(CO)3(pyTAm)] (2) (pyTAm = 2-(pyridyl)imino-triazaadamantane) that can be triggered to release CO upon exposure to visibl...

In this study, we have optimized NMR methodology to determine the thermodynamic parameters of basepair opening in DNA and RNA duplexes by characterizing the temperature dependence of imino proton exchange rates of individual basepairs. Contributions of the nuclear Overhauser effect to exchange rates measured with inversion recovery experiments are quantified, and the influence of intrinsic and ...

Deuteriumand N-induced isotope effects on H and C chemical shifts of the imino moiety of 16 trans-N-benzylideneaniline (tBA) isotopomers were determined and analysed. These effects appear to be a sensitive probe of molecular conformation and its changes. All determined deuterium isotope effects on the imino-proton are small and negative and are spread in the range from −0.88 ppb in 4-H-tBA to −...

Cross-relaxation effects are demonstrated between the imino protons and other protons in yeast tRNAPhe and H2O. A detailed examination has been made of the observed relaxation rate of the proton resonance at 11.8 ppm from DSS as a function of the D2O content in the solvent. This result, as well as the size and number of observed nuclear Overhauser effects, suggests that dipolar magnetization tr...

In the toluene hemisolvated tripodal tris-(2-amino-ethyl)amine Schiff base, C(30)H(33)Cl(3)N(4)O(3)·0.5C(7)H(8), one of the three imino N atoms is protonated, forming a hydrogen bond with the O atom at an adjacent benzene ring. The other two imino N atoms act as hydrogen-bond acceptors from phenolate OH groups. The toluene solvent mol-ecule is disordered about a centre of inversion.

In the title compound, C(10)H(12)ClN(3)OS, the -C=N-N-C- chain bridging the ethyl-imino group and the benzene ring adopts an extended conformation with a C-N-N-C torsion angle of -171.98 (11)°. The imino H atom of the chain is a hydrogen-bond donor to the S atom of an inversion-related mol-ecule, forming a supra-molecular dimer. The hy-droxy H atom is intra-molecularly hydrogen bonded to the az...

The novel amino(imino)germylene 1 was prepared by the conversion of HNIPr (NIPr = bis(2,6-diisopropylphenyl)imidazolin-2-imino) with 1 equiv. of Ge[N(SiMe3)2]2. Germylene 1 reacts with B(C6F5)3 to afford the borate salt 2(+)[MeB(C6F5)3](-) in a methyl-abstraction and ring-closing reaction. The conversion of 2 with Fe2(CO)9 furnishes the germylene iron carbonyl complex 3 with a trigonal planar-c...