Although chronic stress is known to be linked with memory and other neurological disorders, little is known about the relationship between chronic stress and the onset or development of Alzheimer's disease (AD). In this study, we investigated the effects of long-term stress on the onset and severity of cognitive deficits and pathological changes in APPV717I-CT100 mice overexpressing human APP-C...

By measuring levels of noradrenaline (NA) and its major metabolite, 3-methoxy-4-hydroxyphenylethyleneglycol sulfate (MHPG-SO4), in various rat brain regions, the effects of angiotensin II (AT II) injected intracerebroventricularly (ICV) were investigated in non-stressed and stressed rats. Immobilization stress with a wire mesh was employed. Immobilization stress induced significant increases in...

Chronic stress by immobilization during gestation can alter several mechanisms that maintain homeostasis in adrenal gland. The aim of this work was to quantify the apoptotic index of adrenal cortex during mid-pregnancy and to prove cytological characteristics by electron microscopy. The apoptotic index did not present significant differences between the adrenal cortex areas of control and exper...

The effect of the selective 5-HT(1A) receptor agonist 8-hydroxy-2-(di-n-propylamino) tetralin (8-OH-DPAT) on stress-induced anorexia and serotonin (5-HT) release in the rat hypothalamus was studied with brain microdialysis. Subcutaneous injection of 8-OH-DPAT (1 mg/kg) significantly attenuated the immobilization-induced anorexia for 3 h, but had no effect during the following 9 h. Injection of ...

In this issue of Clinical Science, Steptoe et al. [1] report that acute psychological stress in humans (computerized colour-word interference task and mirror tracing) significantly increases the serum concentrations of interleukin-6 (IL-6) and the IL-1 receptor antagonist (IL-1Ra). IL-6 is a pleiotropic cytokine which is involved in T-cell activation, B-cell differentiation and the initiation o...

Stress is known to alter the cellular homeostasis by oxidative damage in brain which in turn involves in various forms of neurotoxicity including neuronal death. The seed powder of the leguminous plant, Mucuna pruriens (MP) has long been used in traditional Ayurvedic Indian medicine for various neurological diseases including Parkinsonism. The neuroprotective and neurorestorative effect of MP w...

Ss who successfully completed 1 wk. of immobilization showed no significant changes in subjective stress and mood or in the urinary excretion of adrenaline and noradrenaline (catecholamines) relative to recumbent controls. On the other hand, the catecholamine excretion of the immobilization quitters was related to their endurance. The early quitters showed no significant changes, whereas the la...

The relationship between the increase in noradrenaline (NA) turnover and endogenous opioid peptides in the hypothalamus under stressful situations was investigated in rats using a specific antagonist of opioids, naloxone. Male Wistar rats were injected subcutaneously with saline, naloxone at 1 mg/kg or 5 mg/kg 10 min before exposure to immobilization stress for 1 hour. Levels of NA and its majo...