نتایج جستجو برای: immune balance
تعداد نتایج: 403636 فیلتر نتایج به سال:
A slightly lower rate of atherosclerosis in some tropical regions such as the Nile delta in Egypt, Saudi Arabia, Yemen and sub-Sahara Africa is associated with evidences of increased helminthic co-infection. Attempts to eradicate helminthic infections led to the shift of immune balance toward T helper 1 cells and their related cytokines. This shift is parallel with atherogenesis and its related...
The interactions between intestinal microbiota, immune system, and pathogens describe the human gut as a complex ecosystem, where all components play a relevant role in modulating each other and in the maintenance of homeostasis. The balance among the gut microbiota and the human body appear to be crucial for health maintenance. Intestinal parasites, both protozoans and helminths, interact with...
Probiotic microflora display numerous health benefits beyond providing basic nutritional value. They cooperatively maintain a delicate balance between the gastrointestinal tract and immune system. When this balance is disrupted, disease and inflammation result. Inflammation and over stimulation of the immune system by pathogenic bacteria are competitively inhibited by mucosal adherence of norma...
The increased presence of sialylated glycans on the tumor surface has been linked to poor prognosis, yet the effects on tumor-specific T cell immunity are hardly studied. We here show that hypersialylation of B16 melanoma substantially influences tumor growth by preventing the formation of effector T cells and facilitating the presence of high regulatory T cell (Treg) frequencies. Knock-down of...
Interaction between the nervous and immune systems greatly contributes to inflammatory disease. In organs at the interface between our body and the environment, the sensory neuropeptide substance P (SP) is one key mediator of an acute local stress response through neurogenic inflammation but may also alter cytokine balance and dendritic cell (DC) function. Using a combined murine allergic infla...
The balance between Th17 and T regulatory (Treg) cells critically modulates immune homeostasis, with an inadequate Treg response contributing to inflammatory disease. Using an unbiased chemical biology approach, we identified a novel role for the dual specificity tyrosine-phosphorylation-regulated kinase DYRK1A in regulating this balance. Inhibition of DYRK1A enhances Treg differentiation and i...
The age-associated dysregulation of the immune response contributes to higher incidences of infectious diseases in the aged. Of note, there is dysregulation of cytokines, including a change in T helper (Th) 1/Th2 cytokine balance and an increase in production of proinflammatory cytokines. Synthesis of many cytokines is influenced by changes in the cellular oxidant/antioxidant balance. Because v...
Many components of the IS are constructed as modular units which do not need to communicate with each other such that the number of components increases but the size remains constant. However, a sub-modular IS architecture in which lymph node number and size both increase sublinearly with body size is shown to efficiently balance the requirements of communication and migration, consistent with ...
Leptin seems to play an important role in the generation and maintenance of immune responses. Leptin is a cytokine similar in structure to interleukin 2, an important T-cell growth factor. Energy balance and supply is increasingly being realised as an important factor in the survival and function of immune cells. Immune responses are intrinsically energy expensive and come at a cost to the resp...
The components of the human gut microbiome have been found to influence a broad array of pathologic conditions ranging from heart disease to diabetes and even to cancer. HIV infection upsets the delicate balance in the normal host-microbe interaction both through alterations in the taxonomic composition of gut microbial communities as well as through disruption of the normal host response mecha...
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