OBJECTIVES To report 10-year outcomes of virological and immunological treatment failure rates and risk factors. DESIGN Prospective cohort study. SETTING Shenzhen, China. PARTICIPANTS 2172 HIV-positive adults in the national treatment database of Shenzhen from December 2003 to January 2014. INTERVENTION Antiretroviral therapy according to the Chinese national treatment guidelines. OUT...

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Background and objectives The features of bullous pemphigoid (BP) patients presenting with mucosal lesions are not established. We aimed to elucidate the clinical immunological BP involvement, identify factors associated lesions. Patients methods A retrospective study encompassing all consecutive diagnosed throughout years 2009–2019 in a tertiary referral center. Results encompassed 273 BP, who...

Inflammatory bowel diseases (IBD), including ulcerative colitis (UC) and Crohn's disease (CD), are chronic inflammatory disorders of the gastrointestinal tract caused by interactions between genetic, environmental, immunological, microbial factors. While incidence prevalence IBD in Asian populations were relatively lower than those Western countries, they appear to be gradually increasing. A We...

The neurodevelopmental hypothesis of schizophrenia posits that schizophrenia is a psychopathological condition resulting from aberrations in neurodevelopmental processes caused by a combination of environmental and genetic factors which proceed long before the onset of clinical symptoms. Many studies discuss an immunological component in the onset and progression of schizophrenia. We here revie...

Spondyloarthritis is a chronic inflammatory rheumatism associated with variety of extra-articular manifestations, including bowel disease (Crohn’s and ulcerative colitis). Subclinical gastrointestinal manifestations in patients spondyloarthritis are common, clinical involvement exists number patients. The pathophysiology remains poorly understood involves genetic immunological factors, as well ...