OBJECTIVE The aims of this study were (1) to examine cerebrovascular autoregulation in subjects with impaired glucose tolerance and type 2 diabetes and (2) to clarify whether cardiovascular autonomic nerve function is associated with abnormal cerebrovascular autoregulation. RESEARCH DESIGN AND METHODS Totally, 46 subjects were recruited (12 = impaired glucose tolerance, 17 = type 2 diabetes a...

Results Researchpublished in the preneuroleptic era suggested thatpeople with severemental illnesswere at increasedriskof developing glycaemic abnormalities.Recent studies appear to confirmthatthe prevalence of diabetes and impairedglucose tolerancemaybe higherinpeoplewith schizophreniathanin the generalpopulation, and suggestthat patientswith schizophrenia have impaired glucose tolerance even ...

Retinol-binding protein-4 (RBP4), a novel protein secreted mainly by adipose tissue, has been associated with insulin resistance in obese subjects and in individuals with type 2 diabetes mellitus (T2DM). We examined the relationship between plasma RBP4 levels, expression of RBP4 in skeletal muscle and adipose tissue, and insulin sensitivity in Mexican Americans with varying degrees of obesity a...

Type 2 diabetes mellitus was once considered a rare disease, but recently there has been an explosive increase in its incidence. Insulin resistance and hyperinsulinemia are characteristics of both type 2 diabetes and impaired glucose tolerance. These metabolic derangements, combined with hypertension and dyslipidemia, common in type 2 diabetes and impaired glucose tolerance, markedly increase t...

The aim of the study was to estimate the rate of coincidence of silent myocardial ischemia episodes with impaired glucose tolerance in patients treated at Outpatient Cardiology Clinic. The study included 93 patients divided into two groups according to the glucose tolerance test results. Study group included 48 subjects with impaired glucose tolerance, while the remaining 45 patients served as ...

Insulin resistance, insulin secretion, and glucose tolerance may predict weight change. A total of 1,194 adults aged 39-69 years at baseline (46% with normal glucose tolerance according to World Health Organization criteria, 23% with impaired glucose tolerance, and 31% with type 2 diabetes mellitus who were not taking insulin) were evaluated at baseline (1992-1994) and after 5 years. Baseline i...

The publication of the Diabetes Control and Complications Trial (DCCT) laid to rest much of the controversy surrounding the role of hyperglycemia in diabetic neuropathy. This study showed that intensive insulin therapy, coupled with improved glycemic control, reduces the severity of diabetic complications and, more importantly, decreases the risk of developing these complications. This was the ...

BACKGROUND Autoantibodies to oxidized low-density lipoprotein (oxLDL) are a heterogeneous group of antibodies that are controversially discussed to be either pathogenic or protective. Biochemical and anthropometric measurements correlated with increased levels of these antibodies are also controversial, especially in conditions of impaired glucose tolerance and type 2 diabetes mellitus. The pre...