نتایج جستجو برای: implicit solvent simulation

تعداد نتایج: 651910  

Journal: :Journal of Chemical Physics 2021

Employing recent advances in response theory and nonequilibrium ensemble reweighting, we study the dynamic static correlations that give rise to an electric field-dependent ionic conductivity electrolyte solutions. We consider solutions modeled with both implicit explicit solvents, different dielectric properties, at multiple concentrations. Implicit solvent models low concentrations small cons...

Journal: :Proteins 2003
Chai-Yu Lin Chin-Kun Hu Ulrich H E Hansmann

We report results from all-atom Monte Carlo simulations of the 36-residue villin headpiece subdomain HP-36. Protein-solvent interactions are approximated by an implicit solvent model. The parallel tempering is used to overcome the problem of slow convergence in low-temperature protein simulations. Our results show that this technique allows one to sample native-like structures of small proteins...

2015
Mark A. Olson Patricia M. Legler Dan Zabetakis Kendrick B. Turner George P. Anderson Ellen R. Goldman

The sequence fitness of a single-domain antibody with unusually high thermal stability is explored by a combined computational and experimental study. Starting with the crystallographic structure, RosettaBackrub simulations were applied to model sequence-structure tolerance profiles and identify key substitution sites. Experimental site-directed mutagenesis was used to produce a panel of mutant...

Journal: :Journal of computer-aided molecular design 2010
Enrico O. Purisima Christopher R. Corbeil Traian Sulea

The SAMPL2 hydration free energy blind prediction challenge consisted of a data set of 41 molecules divided into three subsets: explanatory, obscure and investigatory, where experimental hydration free energies were given for the explanatory, withheld for the obscure, and not known for the investigatory molecules. We employed two solvation models for this challenge, a linear interaction energy ...

2005
Charles F. F. Karney Jason E. Ferrara

When attempting to compute thermodynamic quantities with a molecular simulation, we are frequently confronted with the problem of sampling in a high-dimensional configuration space. The dimensionality of this space is given by the number of degrees of freedom for the molecular system. Techniques which lower the number of degrees of freedom will increase the efficiency of the thermodynamic sampl...

Journal: :Journal of Chemical Theory and Computation 2010

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