Hilary Koprowski, who died this year at the age of 96, was an extraordinary person. He excelled as an innovative scientist, a director of a research institute, a classical pianist, a composer of music, a connoisseur of art, and a polyglot world traveler. Born in Warsaw, Poland, where he obtained a medical degree, the Nazi invasion forced him and his wife, Irena, to flee to Italy, where he studi...

The transitions of antibody therapeutics to late-stage clinical development, regulatory review and the market are proceeding at a rapid pace in 2013. Since late 2012, two monoclonal antibody (mAb) therapeutics (itolizumab, trastuzumab emtansine) received their first approvals, first marketing applications for three mAbs (vedolizumab, ramucirumab, obinutuzumab) were submitted to regulatory agenc...

S ubstantial advances have been made during the past 2 years in various applications of neuroimaging in stroke. Because of limited space, a few major areas in imaging are highlighted here, including developments in selection for acute stroke therapies, hemorrhage, and recovery. Results from several clinical trials have provided important data about imaging selection, including the mismatch conc...

Objectives: The use of electroconvulsive therapy (ECT) varies across countries. The aim of this study was to describe and explore the use of ECT in Sweden in 2013. Methods: The Swedish mandatory patient register of the National Board of Health and Welfare includes information on diagnoses and treatments, including ECT. All 56 hospitals that provide ECT in Sweden also report to the nonmandatory ...

The US Department of Health and Human Services has recommended that adults consume no more than 2,300 mg of sodium per day and that individuals in the following subgroups consume no more than 1,500 mg/day: persons aged ≥51 years; persons with hypertension, diabetes, or chronic kidney disease; and blacks.1 These subgroups account for approximately half of the US population. There is some increas...

The 11th Annual Meeting of Association for Cancer Immunotherapy (CIMT) welcomed more than 700 scientists around the world to Mainz, Germany and continued to be the largest immunotherapy meeting in Europe. Renowned speakers from various fields of cancer immunotherapy gave lectures under CIMT2013's tag: "Advancing targeted therapies" the highlights of which are summarized in this meeting report.

This research analyzed the clinical notes of epilepsy patients using techniques from corpus linguistics and machine learning and predicted which patients are candidates for neurosurgery, i.e. have intractable epilepsy, and which are not. Information-theoretic and machine learning techniques are used to determine whether and how sets of clinic notes from patients with intractable and nonintracta...