Wound dressings that can be formed in situ offer several advantages over the use of preformed dressings such as conformability without wrinkling or fluting in the wound bed, ease of application and improved patient compliance and comfort. Here we describe such an in situ forming hydrogel wound dressing from gelatin, oxidized alginate and borax. Periodate oxidized alginate rapidly cross-links pr...

The biological half-lives and decay rate constants under the conditions of a human brain tumor clonogenic cell assay were determined for six clinically used anticancer agents. The agents studied were: 1,3-bis(2-chloroethyl)-1-nitrosourea; 3-(2-chloroethyl-3-nitrosoureido-2-deoxy-D-glucopyranose; cis-diaminedichloroplatinum(II); 2,5-diaziridinyl-3,6-bis-(carboethoxyamino)-1,4-benzoquinone; 4-dem...

BACKGROUND Ertapenem is a novel carbapenem with activity against both penicillin-susceptible (MIC < or = 0.06 mg/L) and penicillin-non-susceptible (MIC > or = 0.12 mg/L) Streptococcus pneumoniae. This study assessed the pharmacodynamic activity of ertapenem against penicillin-susceptible and penicillin-non-susceptible S. pneumoniae using an in vitro pharmacodynamic model. METHODS Fifteen S. p...

we have analyzed paraffin sections from 55 patients with histologically confirmed hodgkin’s disease (hd) for the presence of epstein-barr virus (ebv) markers using in situ hybridization to detect the ebv-encoded rnas (ebers) and immunohistochemistry to identify latent membrane protein-1 (lmp1) expression. tissue specimens from 55 cases of hodgkin’s disease included 22-mixed cellularity (mc), 27...

purpose : to investigate the application of mitomycin-c 0.02% (mmc) in the photorefractive keratectomy (prk) procedure in correcting regressed myopia methods : eighteen eyes of 11 patients with a spherical equivalent (se) of less than -5 diopters (d) who had undergone laser in situ keratomileusis (lasik) more than 2 years before were operated on. at the end of the prk procedure, mmc was applied...

background:breast cancer remains the most common and second lethal cancer in females. her-2/neu is one of the most important amplified oncogene in breast cancer. the amplification of her-2 is correlated with decreased survival, metastasis, and early recurrence.  the amplification of her-2/neu gene and synthesis of the protein are reported in 10%-34% of breast cancer cases associated with tumor ...