نتایج جستجو برای: inactivated oil emulsion vaccine

تعداد نتایج: 269328  

The purpose of this study is to produce an oil-in-water nano-emulsion by ultrasonication. Casein combined with inulin used as continuous phase, while dispersed phase consisted of fish oil. The size of the nano-emulsion and the pH of nano-emulsion were characterized. Ultrasound has been used for preparing emulsion by 24 KHz intensity for 120 seconds. Prepared nano-emulsion was investigated by pa...

The purpose of this study is to produce an oil-in-water nano-emulsion by ultrasonication. Casein combined with inulin used as continuous phase, while dispersed phase consisted of fish oil. The size of the nano-emulsion and the pH of nano-emulsion were characterized. Ultrasound has been used for preparing emulsion by 24 KHz intensity for 120 seconds. Prepared nano-emulsion was investigated by pa...

Journal: :European journal of internal medicine 2010
Giuseppe Lippi Giovanni Targher Massimo Franchini

Squalene, a hydrocarbon obtained for commercial purposes primarily from shark liver oil and other botanic sources, is increasingly used as an immunologic adjuvant in several vaccines, including seasonal and the novel influenza A (H1N1) 2009 pandemic flu vaccines. Nearly a decade ago, squalene was supposed to be the experimental anthrax vaccine ingredient that caused the onset of Persian Gulf Wa...

Journal: :Journal of preventive medicine and hygiene 2009
D Sindoni V La Fauci R Squeri G Cannavò S Bacilieri D Panatto R Gasparini D Amicizia

The objective of this study was to evaluate and compare the safety, tolerability and immunogenicity for two seasonal influenza subunit vaccines, one with MF59 adjuvant (Fluad) and one without an adjuvant (Agrippal). A total of 195 subjects aged > or = 65 years were enrolled to receive one dose of vaccine intramuscularly, 96 were vaccinated with Fluad, 99 received Agrippal. Blood samples were ta...

Journal: :Expert review of pharmacoeconomics & outcomes research 2006
Gianluca Baio Fabio Pammolli Vincenzo Baldo Renzo Trivello

Influenza infection is a major cause of illness, morbidity and mortality throughout the world, mainly amongst the elderly. Since vaccination has proven to be effective in the reduction of all acute complications, deciding whether to implement a vaccination campaign and which vaccine to prescribe is an important task. The aim of this review is to build a decision model, which allows the decision...

2015
Nicos Karasavvas Chitraporn Karnasuta Hathairat Savadsuk Sirinan Madnote Dutsadee Inthawong Somsak Chantakulkij Surawach Rittiroongrad Sorachai Nitayaphan Punnee Pitisuttithum Prasert Thongcharoen Vinai Siriyanon Charla A. Andrews Susan W. Barnett James Tartaglia Faruk Sinangil Donald P. Francis Merlin L. Robb Nelson L. Michael Viseth Ngauy Mark S. de Souza Robert M. Paris Jean-Louis Excler Jerome H. Kim Robert J. O'Connell

RV144 correlates of risk analysis showed that IgG antibodies to gp70V1V2 scaffolds inversely correlated with risk of HIV acquisition. We investigated IgG antibody responses in RV135 and RV132, two ALVAC-HIV prime-boost vaccine trials conducted in Thailand prior to RV144. Both trials used ALVAC-HIV (vCP1521) at 0, 1, 3, and 6 months and HIV-1 gp120MNgD and gp120A244gD in alum (RV135) or gp120SF2...

Journal: :Vaccine 2014
Carl R Alving Gary R Matyas Oscar Torres Rashmi Jalah Zoltan Beck

Immunotherapeutic vaccines to drugs of abuse, including nicotine, cocaine, heroin, oxycodone, methamphetamine, and others are being developed. The theoretical basis of such vaccines is to induce antibodies that sequester the drug in the blood in the form of antibody-bound drug that cannot cross the blood brain barrier, thereby preventing psychoactive effects. Because the drugs are haptens a suc...

2015
A. CAPANNA G. GERVASI M. CIABATTINI E. VOLPE A. SPADEA S. SGRICIA L. ZARATTI E. FRANCO

INTRODUCTION Adherence to vaccination program for Influenza virus is an important issue of Public Health in presence of many no-vaccine tendencies. The media event about some deaths, occurring after MF59 adjuvanted vaccine administration, has characterized the season 2014/15 vaccination program in Italy. Aim of the study is vaccination adherence assessment of the current season with regards to ...

2011
James S. McCarthy Joanne Marjason Suzanne Elliott Paul Fahey Gilles Bang Elissa Malkin Eveline Tierney Hayley Aked-Hurditch Christopher Adda Nadia Cross Jack S. Richards Freya J. I. Fowkes Michelle J. Boyle Carole Long Pierre Druilhe James G. Beeson Robin F. Anders

BACKGROUND In a previous Phase 1/2b malaria vaccine trial testing the 3D7 isoform of the malaria vaccine candidate Merozoite surface protein 2 (MSP2), parasite densities in children were reduced by 62%. However, breakthrough parasitemias were disproportionately of the alternate dimorphic form of MSP2, the FC27 genotype. We therefore undertook a dose-escalating, double-blinded, placebo-controlle...

Journal: :Drug discoveries & therapeutics 2013
Masahiro Okajima Yuko Wada Takashi Hosoya Fumio Hino Yoshiyasu Kitahara Ken-ichi Shimokawa Fumiyoshi Ishii

Surfactant-free emulsions by adding jojoba oil, squalane, olive oil, or glyceryl trioctanoate (medium chain fatty acid triglycerides, MCT) to electrolytic-reduction ion water containing lithium magnesium sodium silicate (GE-100) were prepared, and their physiochemical properties (thixotropy, zeta potential, and mean particle diameter) were evaluated. At an oil concentration of 10%, the zeta pot...

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