Phage characterization for research and therapy can involve newly isolated phages propagated in pathogenic bacteria. If so, requires safety-managing the In current study, we adapt a common inexpensive reagent, PrimeStore (Longhorn Vaccines Diagnostics, San Antonio, TX, USA), to safety-manage bacteria 20 min by selectively inactivating No bacterial survivors are observed among >109 per ml rep...

Leupeptin~ a proteinase inhibitor obtained from culture f i l t rates of Streptomyces sp.~ has been proposed as a valuable agent for the restriction of proteolysis in vivo. We have previously shown tha t mammalian tissues possess an enzymic system that is capable of inactivating leupeptin (Beynon R39 Brown CP & Butler PEr 1981, Acta Biol. Med. Germ. @0, 153%1546). This paper demonstrates the ub...

The complement system is a crucial component of the innate immune response against invading bacterial pathogens. The human pathogen Neisseria meningitidis (Nm) is known to possess several mechanisms to evade the complement system, including binding to complement inhibitors. In this study, we describe an additional mechanism used by Nm to evade the complement system and survive in human blood. U...