BACKGROUND Statin therapy reduces the risk of occlusive vascular events, but uncertainty remains about potential effects on cancer. We sought to provide a detailed assessment of any effects on cancer of lowering LDL cholesterol (LDL-C) with a statin using individual patient records from 175,000 patients in 27 large-scale statin trials. METHODS AND FINDINGS Individual records of 134,537 partic...

Linac dynamics simulation capabilities of the PyORBIT code are discussed. PyORBIT is an open source code and a further development of the original ORBIT code that was created and used for design, studies, and commissioning of the SNS ring. The PyORBIT code, like the original one, has a two-layer structure. C++ is used to perform time-consuming computations, and the program flow is controlled fr...

background treatment of helicobacter pylori (h. pylori) as a major cause of gastric diseases is of utmost concern.we aimed to assess efficacy of triple therapy (amoxicillin, clarithromycin and pantoprazole) plus probiotic yogurt (py) on eradication of h.pylori. methods total 102 h. pylori positive patients were divided to 3 groups equally and randomly. for treatment of each group amoxicillin, c...

It has previously been shown that osmium tetroxide, pyridine (Os,py) and osmium tetroxide, 2,2'-bipyridine (Os,bipy) are powerful probes of the DNA structure. To increase the possibilities of the detection of osmium-modified DNAs polyclonal antibodies against DNA modified with Os,py and Os,bipy were elicited in rabbits. Specificity of these sera or purified IgG was tested by ELISA and retardati...

The Zaire ebolavirus protein VP24 was previously demonstrated to inhibit alpha/beta interferon (IFN-alpha/beta)- and IFN-gamma-induced nuclear accumulation of tyrosine-phosphorylated STAT1 (PY-STAT1) and to inhibit IFN-alpha/beta- and IFN-gamma-induced gene expression. These properties correlated with the ability of VP24 to interact with the nuclear localization signal receptor for PY-STAT1, ka...

A monoclonal antibody, Py, was produced by immunizing mice with a glycoprotein fraction isolated from 3-week-old rat hippocampus. Py antibodies gave strong immunocytochemical staining of the perikarya and dendrites of large neurons in many areas of the rat brain, including the cerebral cortex, hippocampus, cerebellum, brain stem, and olfactory bulb. Immunoelectron microscopy showed the antigen ...

© 2004 Yoshua Bengio, Olivier Delalleau, Nicolas Le Roux, Jean-Francois Paiement, Pascal Vincent, Marie Ouimet. Tous droits réservés. All rights reserved. Reproduction partielle permise avec citation du document source, incluant la notice ©. Short sections may be quoted without explicit permission, if full credit, including © notice, is given to the source. Série Scientifique Scientific Series ...

Species included in the genus Chalcocopris Burmeister, 1846 are reviewed, including the description of a new species (Chalcocopris inexpectatus sp. nov.) from Central Brazil, and the designation of a neotype for Copris hesperus Olivier, 1789. Pictures, diagnostic characters and an identification key are provided.

In non-anesthetized cats slow-wave sleep (SWS) is composed of sequences of silent (down) and active (up) states; the down states are absent during REM sleep and wake. SWS oscillations ( < 1 Hz ) and their transformation to the active awake state were investigated with computational models of the thalamocortical system. The summation of the miniature EPSPs during depth-positive (silent) phase of...

Introduction The antibacterial efficacy and toxicity of silver nanoparticles (AgNPs) depends on their physicochemical properties including size, shape, surface charge and surface coatings. The Objectives of this study were: i) To synthesize and characterize positively charged AgNPs coated by different ionic-liquids with different alkyl chain lengths, ii) To evaluate the antimicrobial activity o...