Background This study aimed to determine effects of synbiotics on treatment of functional constipation in children aged 2-10 years old. Materials and Methods This randomized single blind clinical trial study carried out on children who had functional constipation based on the Rome III criteria. The  polyethylene glycol + synbiotic group (P+S group, n=38)received the synbiotic with polyethylene ...

background: uterine rupture at the site of a previous cesarean scar is an uncommon but catastrophic complication of pregnancy, which is associated with significant maternal and fetal morbidity and mortality. case presentation: a 30-year old woman at 24th week of gestation and complaint of pain, contractions and spotting was admitted in royan institute in tehran, iran. she had a past medical his...

INTRODUCTION Abdominal pain, bloating, and defecation disturbances are common complaints in gastrointestinal functional disorders. This study explores whether bowel symptoms are correlated to colon transit time (CTT), faecal loading (coprostasis), and colon length; and whether prokinetic intervention can reduce CTT, faecal retention, and symptoms. METHODS This observational and interventional...

INTRODUCTION Constipation is a common problem in intensive care units. We assessed the efficacy and safety of laxative therapy aiming to promote daily defecation in reducing organ dysfunction in mechanically ventilated patients. METHODS We conducted a prospective, randomized, controlled, nonblinded phase II clinical trial at two general intensive care units. Patients expected to remain ventil...

BACKGROUND: Constipation is one of the common problems in childhood and consists of 3% of referrals to pediatricians and 25% of pediatric gastroenterologists. Aperients are common alternatives for treating chronic constipation. The present study aimed to compare the efficacy of three laxatives [polyethylene glycol (PEG), magnesium hydroxide, and lactulose]. METHODS: In this randomized clinical ...

Encopresis is often the result of chronic constipation in the majority of paediatric patients. In clinical practice, however, encopresis is also seen without constipation and it is unknown whether these two clinical variants are based on similar or different pathophysiological mechanisms, requiring different therapeutic approaches. We analysed clinical symptoms, colonic transit time (CTT), oroc...

PURPOSE Stapled transanal rectal resection is advocated for the treatment of obstructed defecation syndrome. Supporting evidence for its safety and effectiveness has been lacking. To address this, the European Stapled Transanal Rectal Resection Registry was initiated in January 2006. This study was designed to analyze 12-month postoperative outcomes of this procedure using data collected in the...

BACKGROUND Constipation and encopresis frequently cause problems with respect to emotional wellbeing, and social and family life. Instruments to measure Health Related Quality of Life (HRQoL) in these disorders are not available. METHODS A disease specific HRQoL instrument, the "Defecation Disorder List" (DDL) for children with constipation or functional non-retentive faecal soiling (FNRFS) w...

To evaluate factors which might contribute to treatment failure in children with chronic constipation and soiling, we evaluated the history, physical findings, defecation dynamics, and anorectal function in 97 patients. We treated them with milk of magnesia, high fibre diet, and bowel training techniques and evaluated outcome at one year when 43% had recovered. Recovery rates were similar for b...

INTRODUCTION Rectal mucosal prolapse syndrome, histologically characterized by fibromuscular obliteration in the lamina propria, hyperplastic glands and thickened muscularis mucosa, causes rectal bleeding. Sjögren's syndrome is an autoimmune exocrinopathy that chiefly destroys the salivary and lacrimal glands by lympho-plasmacytic infiltration. Although various gastrointestinal manifestations h...