Arrhythmias in a Patient With Sarcoidosis. Sarcoidosis is a multisystemic granulomatous disease of unknown etiology; up to 27% of cases entail cardiac involvement. Conduction abnormalities and ventricular tachycardia are the most common arrhythmias and can cause sudden death. We describe a patient who developed cardiac sarcoidosis 9 years after undergoing surgery for neurosarcoidosis. He presen...

Amiodarone, a bi-iodinated benzofuran derivative, is widely used for arrhythmias. Many patients benefit from the effectiveness of amiodarone in treating potentially life-threatening arrhythmias. However, amiodarone-induced pulmonary toxicity (APT) is a severe complication. Even after the discontinuation of amiodarone, not only is APT difficult to manage, but there is also a potentially life-thr...

be induced by stimulus trains for 7.5 seconds only with the BDM or blebbistatin jet (100 nmol/L isoproterenol, 1.0 mmol/L [Ca ]o, 24°C). During sustained arrhythmias, Ca 2 surges preceded synchronous increases in [Ca ]i, whereas the stoppage of the BDM jet made the Ca surges unclear and arrested sustained arrhythmias (n 6). With 200 nmol/L isoproterenol, 2.5 mmol/L [Ca ]o, and the BDM jet, leng...