INTRODUCTION Authors describe human schistosomal granuloma in late chronic phase, from the morphological and evolutionary viewpoints. METHODS The study was based on a histological analysis of two fragments obtained from a surgical biopsy of peritoneum and large intestine of a 42-year-old patient, with a pseudotumoral form mimicking a peritoneal carcinomatosis associated to the schistosomiasis...

The hallmark of Schistosoma mansoni infection is the formation of liver granulomas around deposited ova. The initiation of granuloma formation is T cell-dependent since granulomas are not formed in their absence. We investigated whether a few T cells arrive to initiate the inflammatory lesion and subsequently expand locally, or whether a large repertoire of systemically activated T cells home t...

We have shown previously that the chemokine receptors CXCR3 and CXCR6 are coexpressed by Th1 cells infiltrating the lung and the granuloma of patients with sarcoidosis. In this study, we evaluated the role of CCL20/CCR6 interaction in the pathogenesis of acute and chronic pulmonary sarcoidosis. By flow cytometry and molecular analyses, we have demonstrated that Th1 cells isolated from the bronc...

BACKGROUND The lung is one of the sites of granulomatous responses, which are characterized by the recruitment and organization of activated macrophages and lymphocytes. There have been several reports that have shown that some pulmonary granulomatous diseases, such as sarcoidosis and nontuberculous mycobacterial disease, are likely to be characterized by a preponderance in postmenopausal femal...

BACKGROUND Deposition of uric acid in the kidney can lead to progressive tubulointerstitial injury with granuloma formation. We hypothesized that uric acid crystal deposition may induce granuloma formation by stimulating local expression of macrophage migration inhibitory factor (MIF), which is a known mediator of delayed type hypersensitivity (DTH). MATERIALS AND METHODS A model of acute uri...

Acute schistosomiasis is characterized by pro-inflammatory responses against tissueor organ-trapped parasite eggs along with granuloma formation. Here, we describe studies in Cx3cr1 mice and demonstrate the role of Cx3cr1 in the pathoetiology of granuloma formation during acute schistosomiasis. Mice deficient in Cx3cr1 were protected from granuloma formation and hepatic injury induced by Schist...

INTRODUCTON: Many lesions of the jaws contain giant cells, they include Peripheral giant cell granuloma, Central giant cell granuloma, aneurismal bone cyst, brown tumor of hyperparathyroidism and early stage of cherubism. Giant cell granuloma which is a benign bone lesion that occurs mainly in the jaws are not tumor but tumor like conditions, the cause of tumor like condition is chronic truma w...

in patients with malignancy, the common etiologies of granuloma formation are tumor related sarcoid reaction, sarcoidosis, tuberculosis and other granulomatous diseases. often, the finding of granulomas in malignant patients may obscure the primary malignancy or may mislead towards treatment of infectious and other etiologies. hence, their proper recognition and necessary follow up is needed to...

Plan: Anti-inflammatory evaluation of abyssinone V-4’-methyl ether. Prologue: The anti-inflammatory activity of abyssinone V-4'-methyl ether, a natural prenylated flavonoid isolated from the bark of Erythrina droogmansiana (Leguminosae) was evaluated using acute and chronic inflammation models in vivo namely carrageenan-induced paw edema in rats, xylene induced-ear edema in mice and cotton pell...

STATEMENT OF THE PROBLEM Peripheral and central giant cell granuloma are two common benign lesions of the oral cavity. In spite of histopathological similarities, they have different clinical behaviors. Cathepsin D is a lysosomal enzyme which has different functions on the basis of protein and applied peptide cleavage. PURPOSE This research aimed to evaluate and compare the expression level o...