نتایج جستجو برای: induced hepatotoxicity
تعداد نتایج: 981459 فیلتر نتایج به سال:
The antioxidant effect of aqueous-ethanolic extract from Astragalus glycyphylloides (Fabaceae), and its protection against carbon tetrachloride-induced hepatotoxicity were investigated in male Wistar rats. For seven consequent days the animals were treated orally with A. glycyphylloides extract (EAG) (100 mg/kg). Two hours after the last administration the animals were charged with carbon tetra...
Objective(s): The objective of this study was to investigate the hepatoprotective effect of licochalcone B (LCB) in a mice model of carbon tetrachloride (CCl4)-induced liver toxicity. Materials and Methods: Hepatotoxicity was induced in mice by a single subcutaneous injection (SC) of CCl4. The LCB was administered orally once a day for seven days (PO) as pretreatment at three doses of 1, 5, and...
Background: Malathion (MT), an organophosphorus pesticide, induces hepatotoxicity and is associated with hyperglycemia and the development of diabetes mellitus. Objectives: This study was aimed to evaluate the effects of sub-acute exposure to sub-lethal dose of MT in the liver of diabetic rats. Methods: Non-diabetic and streptozotocin-induced diabetic rats received MT at a dose of 150 mg/kg...
Lysosomal Cholesterol Accumulation Sensitizes To Acetaminophen Hepatotoxicity by Impairing Mitophagy
The role of lysosomes in acetaminophen (APAP) hepatotoxicity is poorly understood. Here, we investigated the impact of genetic and drug-induced lysosomal cholesterol (LC) accumulation in APAP hepatotoxicity. Acid sphingomyelinase (ASMase)(-/-) mice exhibit LC accumulation and higher mortality after APAP overdose compared to ASMase(+/+) littermates. ASMase(-/-) hepatocytes display lower threshol...
Cadmium (Cd) is widely used in some industries and emitted from fossil fuels. It a heavy metal with number of side effects, including hepatotoxicity. Resveratrol (Rs) considered an important polyphenol, which secondary plant metabolite has the ability to scavenge free radicals. The study was designed evaluate effects resveratrol on Cd, induced hepatotoxicity, by assessment histopathological bio...
in the present study, an attempt was made to develop galactosylated albumin nanoparticles of cimetidine for treatment of acetaminophen induced hepatotoxicity. by developing the galactosylated nanoparticulated delivery of cimetidine the required action of drug at the target site i.e at liver can be provided. the advantage of targeting helps to reduce the systemic side effects which may be occur ...
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