BACKGROUND The causative agent of visceral leishmaniasis (VL) in Iran is Leishmania infantum (L. infantum) (Mediterranean type) and its major reservoir host is the dog. OBJECTIVE To compare the serological methods including direct agglutination test (DAT), indirect immunofluorescent-antibody test (IFA) and enzyme-linked immunosorbent assay (ELISA) for serodiagnosis of endemic strain of L. inf...

background: lipophosphoglycan 3 (lpg3) is required for the lpg assembly, a well known virulent molecule. in this study, the lpg3 gene of the lizard and mammalian leishmania species were cloned and sequenced. a three-dimensional structure (3d) for the target sequence was also predicted by comparative (homology) modeling. materials and methods: an optimization pcr amplification was performed on g...

clinically infected dogs have been identified as the main reservoir hosts of visceral leishmaniasis (vl)caused by leishmania infantum. recently asymptomatic infected dogs were regarded to be as important asclinically ill dogs. this study was aimed to determine the seroprevalence of l. infantum infection amongasymptomatic dogs in the southwest and central parts of iran and to investigate possibl...

visceral leishmaniasis (vl) is an emerging zoonosis disease in countries of the mediterranean basin caused by leishmania infantum. although domestic dogs are the main vertebrate hosts, many wild carnivores have been considered playing a role in the spreading of vl. sporadic numbers of dog and human vl have been reported in golestan province in north iran. the present study was performed to dete...

background: mediterranean visceral leishmaniasis (mvl) is an infectious disease that affects both human and ani­mals. domestic dogs ( canis familiaris ) are principal reservoir hosts of mvl caused by leishmania infantum . dogs are definitive hosts for neospora caninum and a risk factor for infecting intermediate hosts. the immunosuppression caused by visceral leishmaniasis (vl) can promote the ...

Phlebotomus perniciosus is one of the major vectors of Leishmania infantum in the Mediterranean basin. The aim of this work was (i) to provide information about abundance and temporal dynamics of this Larroussius species in a hot spot area of visceral leishmaniasis in Tunisia, (ii) to detect L. infantum DNA in wild caught female sandflies and (iii) to measure Phlebotomus perniciosus infection r...

Visceral leishmaniasis (VL) is one of the most severe clinical manifestations as it leads to death in 90% untreated cases. The liver, spleen and bone marrows are organs affected; however, Leishmania parasites able reach intestines where gut-associated lymphoid tissue (GALT) located. Under physiological conditions, gastrointestinal tract GALT interact with enteric nervous system (SNE); there no ...

In an effort to explore herbal drugs as treatment for some neglected tropical diseases (NTDs), Severinia buxifolia (Poir) Ten, was selected and investigated its antiprotozoal activity. Based on this objective, the ethyl acetate (EA), n-hexane (HE), methylene chloride (MC), n-butanol (BU) fractions of leaves S. were screened in vitro activity against Plasmodium falciparum, Trypanosoma brucei, cr...