Inflammation serves a protective function in controlling infections and promoting tissue repair, and can also cause damage to tissue and disease. Many types of cells involved in this process, expressing the components of the cannabinoid signaling system that can be controlled endogenously or pharmacologically. Cannabinoids inhibit neuroinflammation and the immune cells express the whole machi...

Inflammation is a protective response that occurs in to tissue injury and microbial infections. A significant advancement has been made our understanding of inflammation, which one the most fundamental concepts medicine. Immunoregulation immune-mediated inflammatory diseases depends on Th17/Treg balance. Costimulatory receptors, cytokines, metabolic pathways, intestinal microbiome all affect th...

Periodontitis is a common inflammatory disease. It characterized by destruction of the supporting structures teeth and could lead to tooth loss systemic inflammation. Bacteria in inflamed gingival tissue virulence factors are capable entering bloodstream induce response, thus influencing pathological process many diseases, such as cardiovascular diabetes, chronic kidney disease, well liver inju...

Coronavirus disease 2019 (COVID-19) viral infection, like other infections, triggers an inflammatory response that is usually confined to the respiratory system. However, there evidence in a full-blown case, almost all systems of body may be involved. In addition, syndrome cytokine storm, characterized by severe systemic inflammation and massive release proinflammatory cytokines (1). It well es...

BACKGROUND Unemployment is a source of acute and long-term psychosocial stress. Acute and chronic psychosocial stress can induce pronounced changes in human immune responses. In this study we tested our hypothesis that stress-induced low-grade tissue inflammation is more prevalent among the unemployed. METHODS We determined the inflammatory status of 225 general population subjects below the ...

Expression of the transcription factor FoxP3 is the hallmark of regulatory T cells that play a crucial role in dampening immune responses. A comparison of the development and phenotype of FoxP3(+) T cells in relation to the expression of conventional MHC molecules facilitated the identification of several distinct lineages of naive and effector/memory populations of Foxp3(+) T cells. One subpop...

The body relies for protection on an effective inflammatory response. To sustain an armoury of inflammatory cells in a state of permanent activation would be impossible and a system whereby such cells can be rapidly activated is, therefore, employed. Upon transition from the resting to activated state inflammatory cells perform multiple defensive functions and are then removed, limiting the dur...