Abstract The root of Angelica sinensis (Oliv.) Diels, a well-known Chinese herbal medicine, has been used historically as hematopoietic and anti-inflammatory agents for thousands years. Recent phytochemistry pharmacological studies have proved that polysaccharides are one the major active ingredients in A. . It demonstrated ASPs ( polysaccharides) had various important biological activities, su...

Nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) is responsible for the regulation genes involved in inflammation and immune responses. NF-κB may play an important role cardiovascular diseases (CVDs), atherosclerosis diabetes. Several therapeutic agents used treatment CVDs diabetes, such as pimobendan sodium–glucose cotransporter 2 inhibitors, exert anti-inflammatory effec...

Inflammation is associated with the development of several diseases comprising cancer and cardiovascular disease. Agents that suppress cyclooxygenase (COX) lipoxygenase (LOX) enzymes, besides chemokines have been suggested to minimise inflammation. Here, a variety novel heterocyclic non-heterocyclic compounds were prepared from three furanone derivatives. The structures all synthesised confirme...

Colorectal cancer (CRC) is one of the most common human malignancies and a leading cause of cancer-related deaths in developed countries. Identifying effective preventive strategies aimed at inhibiting the development and progression of CRC is critical for reducing the incidence and mortality of this malignancy. The prevention of carcinogenesis by anti-inflammatory agents including nonsteroidal...

The etiology of inflammatory bowel disease (IBD) has not yet been clarified and immunosuppressive agents which nonspecifically reduce inflammation and immunity have been used in the conventional therapies for IBD. Evidence indicates that a dysregulation of mucosal immunity in the gut of IBD causes an overproduction of inflammatory cytokines and trafficking of effector leukocytes into the bowel,...