TNFα is one of the most important inflammatory cytokines which induces caspase and apoptotic process. There are two forms of TNFα: soluble TNFα (solTNFα) and transmembrane TNFα (tmTNFα). These inflammatory cytokines have two receptors namely TNRF1 and TNRF2. The attachments of the cytokines to those receptors induce the TRAF and activate the NK-Kb. TNFR1 is f...

Neuro-inflammation is a reaction to brain injury involving the activation of glial cells and release of inflammatory mediators, such as cytokines and chemokines which has a key role in neuro-degenerative diseases. Periodontitis is a microbiome-related dental inflammation caused by gram- negative bacteria that leads to connective tissue destruction and loss of teeth. Previous studies demonstrated...

inflammatory responses and innate immunologic reactions play an important role in the respiratory system. ex vivo lung perfusion (evlp) is considered a novel method in the evaluation and reconditioning of donor lungs prior to transplantation. however, evlp’s effect on inflammatory and metabolic markers of human lung tissue is unknown. this study investigated how the performance of evlp on brain...

Abstract Dose of Trp53 , the main keeper genome stability, influences tumorigenesis; however, causes underlying and driving tumorigenesis over time by loss a single p53 allele are still poorly characterized. Here, we found that specifically impacted oxidative, DNA damage inflammatory status hematopoietic lineages. In particular, in mice triggered oxidative stress peripheral blood granulocytes s...

Inflammatory bowel disease (IBD) is characterized by gastrointestinal inflammation comprised of Crohn's and ulcerative colitis. Centers for Disease Control Prevention report that 1.3% the population United States (approximately 3 million people) were affected in 2015, number keeps increasing over time. IBD has a multifactorial etiology, from genetic to environmental factors. Most treatments rev...