Abstract Inflammatory Bowel Disease (IBD) is a chronic inflammatory disease that affects the epithelial lining of gastrointestinal tract. Recent single cell RNA-sequencing (scRNA-seq) studies suggested inflammation-associated fibroblasts (IAFs) play important roles in pathogenesis and drug resistance. To elucidate IAF’s role IBD, we isolated from patients with IBD profiled their responses to pa...

conclusions while the crp value was in patients with acute brucellosis in the current study, the mpv, rdw and leukocyte counts were within the normal range. crp value remains the most valuable inflammatory marker in cases of acute brucellosis. results the follow-up within the year after treatment was examined. the values of age, gender, leukocyte count, c-reactive protein, rdw and mpv were reco...

Macrophages have long been known to play a major role in the pathogenesis of proliferative vitreoretinal disorders. Using the monoclonal antibodies EBM11 (pan macrophage), 27E10 (early inflammatory stage marker), and RM3/1 (healing phase marker), different subpopulations of macrophages were differentiated in surgically removed membranes from patients with macular pucker (n = 6), proliferative v...

Peripheral arterial disease (PAD) is an important manifestation of atherosclerosis, with increasing prevalence worldwide. A growing body of evidence shows that the systemic inflammatory response is closely related to the development, progression, and prognosis of atherosclerosis. In the last decade, several studies have suggested the role of measured inflammatory biomarkers as predictors of sev...

Advanced glycation end products (AGEs) are major inflammatory mediators in diabetes, affecting atherosclerosis progression via macrophages. Metformin slows diabetic atherosclerosis progression through mechanisms that remain to be fully elucidated. The present study of murine bone marrow derived macrophages showed that (1) AGEs enhanced proinflammatory cytokines (interleukin-1β (IL-1β), IL-6, an...

Rheumatoid factor (RF) is an important marker of many autoimmune diseases. Presence of RF is characteristic for rheumatoid arthritis and other inflammatory diseases of various underlying

In this case study, I report on a patient with stage IV ovarian cancer and underlying pro-inflammatory comorbidities. Initially, the patient's inflammatory condition was treated with an intensive integrative anti-inflammatory protocol using a combination of oral and intravenous nutrients and botanicals along with pharmaceutical intervention. This was followed by a standard course of chemotherap...

INTRODUCTION Neuroticism is an important marker of vulnerability for both mental and physical disorders. Its link with multiple etiological pathways has been studied before. Inflammatory markers have been demonstrated to predict similar mental and physical disorders as neuroticism. However, currently no study has focused on the shared genetic background of neuroticism and inflammatory markers. ...

small supernumerary marker chromosomes (ssmc) are still a major problem in clinical cytogenetics as they cannot be identified or characterized unambiguously by conventional cytogenetics alone. on the other hand, and perhaps more importantly in prenatal settings, there is a challenging situation for counseling how to predict the risk for an abnormal phenotype, especially in cases with a de novo ...