نتایج جستجو برای: influenza a h7n9 virus

تعداد نتایج: 13592173  

2015
Zhongfang Wang Yanmin Wan Chenli Qiu Sergio Quiñones-Parra Zhaoqin Zhu Liyen Loh Di Tian Yanqin Ren Yunwen Hu Xiaoyan Zhang Paul G. Thomas Michael Inouye Peter C. Doherty Katherine Kedzierska Jianqing Xu

The avian origin A/H7N9 influenza virus causes high admission rates (>99%) and mortality (>30%), with ultimately favourable outcomes ranging from rapid recovery to prolonged hospitalization. Using a multicolour assay for monitoring adaptive and innate immunity, here we dissect the kinetic emergence of different effector mechanisms across the spectrum of H7N9 disease and recovery. We find that a...

2013
Wendong Liu Yefei Zhu Xian Qi Ke Xu Aihua Ge Hong Ji Jing Ai Changjun Bao Fenyang Tang Minghao Zhou

A novel avian influenza A (H7N9) virus was discovered in February 2013 in China and has resulted in more than 100 comfirmed human infections including 26 fatal cases as of May 2, 2013. The situation raises many urgent questions and global public health concerns. In this study, epidemiologic characteristics of infected human cases in Jiangsu province were analyzed and risk assessment was underta...

2015
Huihui Kong Qianyi Zhang Chunyang Gu Jianzhong Shi Guohua Deng Shujie Ma Jinxiong Liu Pucheng Chen Yuntao Guan Yongping Jiang Hualan Chen

The continued spread of the newly emerged H7N9 viruses among poultry in China, together with the emergence of drug-resistant variants and the possibility of human-to-human transmission, has spurred attempts to develop an effective vaccine. An MF59-adjuvant H7N9 inactivated vaccine is reported to be well-tolerated and immunogenic in humans; however a study in ferrets indicated that while a singl...

Journal: :Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin 2013
J Han M Jin P Zhang J Liu L Wang D Wen X Wu G Liu Y Zou X Lv X Dong B Shao S Gu D Zhou Q Leng C Zhang K Lan

We analysed the association between influenza A(H7N9) confirmed cases and exposure to poultry in Huzhou city, China. All cases (n=12) had a history of direct exposure to poultry or live poultry markets. We detected A(H7N9)-positive poultry samples from each site that was epidemiologically associated with cases. None of the cases’ close contacts tested positive. After closure of the markets, no ...

Journal: :The New England journal of medicine 2013
Timothy M Uyeki Nancy J Cox

S disease in humans caused by a novel influenza A virus that is distinct from circulating human influenza A viruses is a seminal event. It might herald sporadic human infections from an animal source — e.g., highly pathogenic avian influenza (HPAI) A (H5N1) virus; or it might signal the start of an inf luenza pandemic — e.g., influenza A(H1N1)pdm09 virus. Therefore, the discovery of novel influ...

2013
Yi Zhang Yong-Sheng Yu Zheng-Hao Tang Xiao-Hua Chen Guo-Qing Zang

BACKGROUND Characterisation of the severity profile of human infections with influenza viruses of animal origin is a part of pandemic risk assessment, and an important part of the assessment of disease epidemiology. Our objective was to assess the clinical severity of human infections with avian influenza A H7N9 virus, which emerged in China in early 2013. METHODS We obtained information abou...

2017
Eun Jin Choi Han Sol Lee Ji Yun Noh Joon Young Song Hee Jin Cheong Ok Sarah Shin Hyojin Lee Moonsup Jeong Woo Joo Kim

BACKGROUND In March 2013, human infection with avian influenza A (H7N9) virus emerged in China, causing serious public health concerns and raising the possibility of avian-source pandemic influenza. Thus, the development of an effective vaccine for preventing and rapidly controlling avian influenza A (H7N9) virus is needed. In this study, we evaluated the immunogenicity of a synthetic DNA vacci...

Journal: :Journal of virology 2014
Florian Krammer Randy A Albrecht Gene S Tan Irina Margine Rong Hai Mirco Schmolke Jonathan Runstadler Sarah F Andrews Patrick C Wilson Rebecca J Cox John J Treanor Adolfo García-Sastre Peter Palese

UNLABELLED The emergence of avian H7N9 viruses in humans in China has renewed concerns about influenza pandemics emerging from Asia. Vaccines are still the best countermeasure against emerging influenza virus infections, but the process from the identification of vaccine seed strains to the distribution of the final product can take several months. In the case of the 2009 H1N1 pandemic, a vacci...

2014
Chen Wang Hongjie Yu Peter W. Horby Bin Cao Peng Wu Shigui Yang Hainv Gao Hui Li Tim K. Tsang Qiaohong Liao Zhancheng Gao Dennis K. M. Ip Hongyu Jia Hui Jiang Bo Liu Michael Y. Ni Xiahong Dai Fengfeng Liu Nguyen Van Kinh Nguyen Thanh Liem Tran Tinh Hien Yu Li Juan Yang Joseph T. Wu Yaming Zheng Gabriel M. Leung Jeremy J. Farrar Benjamin J. Cowling Timothy M. Uyeki Lanjuan Li

BACKGROUND Influenza A(H7N9) viruses isolated from humans show features suggesting partial adaptation to mammals. To provide insights into the pathogenesis of H7N9 virus infection, we compared risk factors, clinical presentation, and progression of patients hospitalized with H7N9, H5N1, and 2009 pandemic H1N1 (pH1N1) virus infections. METHODS We compared individual-level data from patients ho...

2015
Ji-Rong Yang Chuan-Yi Kuo Hsiang-Yi Huang Fu-Ting Wu Yi-Lung Huang Chieh-Yu Cheng Yu-Ting Su Ho-Sheng Wu Ming-Tsan Liu

A novel avian influenza A (H7N9) virus causes severe human infections and was first identified in March 2013 in China. The H7N9 virus has exhibited two epidemiological peaks of infection, occurring in week 15 of 2013 and week 5 of 2014. Taiwan, which is geographically adjacent to China, faces a large risk of being affected by this virus. Through extensive surveillance, launched in April 2013, f...

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