background: gestational diabetes mellitus (gdm) is a form of diabetes that occurs in pregnancy. gdm, defined as glucose intolerance, first diagnosed or initiated during pregnancy affects 1-14% of pregnancies based on various studies. screening and early diagnosis and appropriate glycemic control can improve prenatal outcomes. telephone follow-up seems to be a reasonable way for pregnant women f...

background: one of the main causes of adverse complications following kidney transplantation is urinary tract infection (uti). this study was done to define the incidence rate, clinical profiles, causative microorganisms, and uti risk factors among kidney transplant recipients in mashhad city. materials and methods: in this retrospective study, we perused medical files of 247 kidney recipients ...

conclusions the current results showed no significant differences between the outcomes of the two procedures at short-term follow-up. however, the results might have changed in the long term. background stress urinary incontinence in women is a common problem that impairs the quality of life in patients. the extraordinary number of procedures to treat stress urinary incontinence reflects a lack...

Localized and systemic cytokine production in virus-infected cells play an important role in the outcome of viral infection and pathogenicity. Activation of the interferon regulatory factors (IRF) in turn is a critical mediator of cytokine gene transcription. Recent studies have focused on the 55-kDa IRF-3 gene product as a direct transcriptional regulator of type 1 interferon (IFN-alpha and IF...

The rapid induction of alpha interferon (IFN) and IFNexpression plays a critical role in the innate immune response against viral infection. We studied the effects of transforming growth factor (TGF) and its intracellular effectors, the Smads, on the function of IRF-7, an essential transcription factor for IFNand induction. IRF-7 interacted with Smads, and IRF-7, but not IRF-3, cooperated with ...

although tadao ando never refers to phenomenology explicitly, concentrating on his numerous texts and writings reveals that his way of thinking on architecture implies some essential themes and concerns, which are fundamentally related to the “phenomenological discourse” in both philosophy and architecture. concepts and ideas such as :union: of subject and object, space, body and movement, memo...

Abstract BACKGROUND This study evaluates O-(2-[18F]fluoroethyl)-L-tyrosine (FET) PET and contrast-enhanced MRI for early response assessment in glioma patients at recurrence treated with lomustine-based chemotherapy. METHODS Thirty-six adult WHO CNS Grade 3 or 4 gliomas (glioblastoma, 69%) (median number of recurrences, 1; range, 1-3) were retrospectively identified. Besides MRI, serial FET sca...

Previously, we demonstrated that pyroptosis in alveolar macrophages (AMs) plays an essential role in lipopolysaccharide (LPS)-induced acute lung injury. However, the underlying mechanism remains largely unclear. Here, we show that the absence of interferon regulatory factor 1 (IRF-1) in genetic knock-out mice strongly abrogates pyroptosis in AMs and alleviates the LPS-induced lung injury and sy...

The Epstein-Barr virus (EBV) BamHI Q promoter (Qp) is the only promoter used for the transcription of Epstein-Barr virus nuclear antigen 1 (EBNA-1) mRNA in cells in the most restricted (type I) latent infection state. However, Qp is inactive in type III latency. With the use of the yeast one-hybrid system, a new cellular gene has been identified that encodes proteins which bind to sequence in Q...

Alveolar macrophages and newly recruited monocytes are targets of infection by Mycobacterium tuberculosis. Therefore, we examined the expression of interferon regulatory factor 1 (IRF-1), which plays an important role in host defense against M. tuberculosis, in undifferentiated and differentiated cells. Infection induced IRF-1 in both. IRF-1 from undifferentiated, uninfected monocytic cell line...