Apoptosis is a cellular process that leads to the death of damaged cells. Its malfunction can cause cancer and poor response to conventional chemotherapy. After being activated by cellular stress signals, pro-apoptotic proteins bind anti-apoptotic proteins, thus allowing apoptosis to go forward. An excess of anti-apoptotic proteins can prevent apoptosis. Designed molecules that imitate the role...

Synthetic biology has enabled the creation of biological reconfigurable circuits, which perform multiple functions monopolizing a single biological machine; Such a system can switch between different behaviours in response to environmental cues. Previous work has demonstrated switchable dynamical behaviour employing reconfigurable logic gate genetic networks. Here we describe a computational fr...

Extended-spectrum-β-lactamases (ESBLs), constitutes the growing class of betalactamses, these are enzymes produced by bacteria which impart resistance against advanced-generation-cephalosporins. SHV enzymes are among the most prevalent ESBLs. The mode of molecular interactions of recent SHV-variants to advanced generation cephalosporins has not been reported yet. This is the first time we are r...

The chaperone BiP participates in several regulatory processes within the endoplasmic reticulum (ER): translocation, protein folding, and ER-associated degradation. To facilitate protein folding, a cooperative mechanism known as entropic pulling has been proposed to demonstrate the molecular-level understanding of how multiple BiP molecules bind to nascent and unfolded proteins. Recently, exper...

Oats (Avena sativa L.) have been used as livestock and human foods since ancient times. It is a good source of many active phytocompounds which exhibit antiinflammatory, anti-oxidant and anti-colon cancer activities. In the present study, an insilico approach was followed to identify the potential phytocompounds of oats against anticolon cancer. Fourteen phytocompounds of oats were selected as ...

DNA sample contamination is a serious problem in DNA sequencing studies, and may result in systematic genotype misclassification and false positive associations. While methods exist to detect and filter out cross-species contamination, few methods to detect within-species sample contamination are available. In this paper, we describe methods to identify withinspecies DNA sample contamination ba...

Objective: In day to day life, occupational stress is responsible for oxidative stress by altering sleep cycle. Scopolamine induction of amnesia correlates to stress-induced amnesia in youngsters. Hence, the present study was aimed to investigate the anti-amnesic effect of ethanolic extract and ethyl acetate fraction of Sargassum ilicifolium Turner (C. Agardh) against scopolamine. Methods: In t...

'Conserved hypothetical' proteins pose a challenge not just for functional genomics, but also to biology in general. As long as there are hundreds of conserved proteins with unknown function in model organisms such as Escherichia coli, Bacillus subtilis or Saccharomyces cerevisiae, any discussion towards a 'complete' understanding of these biological systems will remain a wishful thinking. Insi...

Structural genomics (SG) is an international effort that aims at solving three-dimensional shapes of important biological macro-molecules with primary focus on proteins. One of the main bottlenecks in SG is the ability to produce diffraction quality crystals for X-ray crystallography based protein structure determination. SG pipelines allow for certain flexibility in target selection which moti...

Skin is the most extended organ in human body representing 16% of total weight with a surface extension up to 2 m2. From mechanical viewpoint, skin can be described by an hyperelastic membrane, particularly when computational modeling for insilico testing reconstructive surgery procedures needed. These often involves complex topological manipulations tissue order minimize post-operative scarrin...