in this study, the effects of late gestational undernutrition (lgu) on plasma concentration of insulin-like growth factor 1 (igf-i), leptin, insulin and glucose in subsequent sucking lambs was investigated. ten twin-bearing ewes were fed either restrictedly (restricted) or adequately (control) during the last six weeks of gestation and were fed ad libitum after parturition. blood samples were t...

INTRODUCTION In the study we investigated the association between IGFs, their binding proteins and pathogenesis as well as prognostic factors of relapse of childhood ALL. MATERIAL AND METHODS In 43 children suffering from ALL, we observed 7 cases of relapse. We studied the serum levels IGF-I, IGF-II, IGFBP-3 and IGFBP-2 (expressed in SDS) in a subgroup with relapse (A) and in a subgroup witho...

critical in the control of the secretion of insulin like growth factor I' Interestingly, high concentrations of this growth factor have been found in patients with progressive exudative lesions.' Our findings suggest that growth hormone is not essential for the initiation and development of diabetic retinopathy. Our patient's normal concentrations of insulin like growth factor I and her growth ...

BACKGROUND Studies have shown a positive association between serum insulin-like growth factor (IGF)-I and breast cancer risk in premenopausal but not postmenopausal women. IGF-II and estrogen receptor (ER) status has never been investigated. We examined the association between IGF-I, IGF-II, IGF binding protein (IGFBP)-2, IGFBP-3, and IGFBP-3 protease activity and breast cancer risk in postmeno...

Introduction IGF-1 regulates normal and neoplastic growth in the prostate (1), and higher serum IGF-1 levels (2) appear to increase prostate cancer risk in epidemiological studies. Other aspects of the IGF axis, such as IGFBP-3 (3), inconsistently affect risk. Retrospective studies dominate the literature on this topic, and we, therefore, investigated IGF-I and IGFBP-3 in a pilot study from the...

Insulin-like growth factor-binding proteins (IGFBPs) control bioavailability, activity, and distribution of insulin-like growth factor (IGF)1 and -2 through high-affinity IGFBP/IGF complexes. IGF-binding sites are found on N- and C-terminal fragments of IGFBPs, the two conserved domains of IGFBPs. The relative contributions of these domains to IGFBP/IGF complexation has been difficult to analyz...

Insulin-like growth factors (IGFs) play key roles in cell proliferation and apoptosis. Whereas relatively stable within individuals, IGFs vary substantially between individuals, and a large component of this variation may be determined by genetic factors. Several polymorphisms in IGF genes have been identified, although their functional significance is not clear. We evaluated the association of...