Los insulinomas son los tumores neuroendocrinos más frecuentes, la mayoría benignos y se localizan en el páncreas. Pueden ser esporádicos o estar asociadas a neoplasia endocrina múltiple tipo 1 (NEM1). Para realizar un diagnóstico oportuno es clave considerarlo diferencial de paciente no diabético que presenta con una hipoglicemia. La presentación clínica (tríada Whipple), pruebas bioquímicas c...

Insulinoma is a rare functioning endocrine tumor of the beta cells of the pancreatic islet of Langerhans. The clinical picture presented is due to episodes of hypoglycemia induced by increased secretion of insulin by the tumor. Harris in 1924 was the first to suggest the possibility of spontaneous hypoglycemia, and in 1927 Wilder made the first reported preoperative diagnosis of an insulin-secr...

Insulinoma is a rare pancreatic islet cell tumor, the most common cause of hypoglycemia related to endogenous hyperinsulinism. We present the case of an adult patient with pancreatic insulinoma. The patient presented to our clinic after prior hospitalizations in diabetes and psychiatry hospital units for repeated episodes of loss of consciousness, sweating and tonic-clonic seizures. Early detec...

Insulinoma is a rare pancreatic endocrine tumour and is typically sporadic and solitary. Over 90% of all insulinomas are benign. Cystic insulinomas are also rare. It is not difficult to determine the site of such neoplasm, as cystic insulinomas are usually 4-10 cm in diameter. We present the case of a patient with a histologically confirmed cystic insulinoma diagnosed after approximately 10 yea...

Three Japanese patients (a man and his two sons) in a family with clinical diagnosis of familial multiple endocrine neoplasia type 1 (MEN1) suffered from insulinoma(s), primary hyperparathyroidism and pituitary microadenoma. Genomic DNA of the patients was analyzed by sequencing for the MEN1 gene and an insertion of six nucleotides, CTGCAG, in exon 4, resulting in insertion of two amino acids, ...

We report the case of an obese 79-year-old woman who experienced postprandial hypoglycemia in the morning. The serum immunoreactive insulin (IRI) and C-peptide levels responded in parallel with her serum glucose level during a 75-g oral glucose tolerance test. A prolonged fast test lowered her serum glucose level to 30 mg/dL, but serum IRI was not fully suppressed. Abdominal computed tomography...

A 73-year-old woman with malignant insulinoma was treated with 100 μg/day octreotide for unresected insulinoma and liver metastases. The daily administration of the drug induced hyperglycemia after dinner in addition to existing fasting hypoglycemia possibly because this drug suppressed both insulin and glucagon secretion and its blood concentration was unstable. After replacing a daily injecti...

Hyperinsulinism due to dumping syndrome following gastric surgery is an uncommon condition. It is specified with hypoglycemic attacks. However, linking symptoms to dumping syndrome in each patient to whom gastric surgery was performed leads to inappropriate diagnosis and therapy. Insulinoma and other causes that give rise to hyperinsulinemia should not be ignored and these diagnoses should be e...