Protein-protein interactions, a key to almost any biological process, are mediated by molecular mechanisms that are not entirely clear. The study of these mechanisms often focuses on all residues at protein-protein interfaces. However, only a small subset of all interface residues is actually essential for recognition or binding. Commonly referred to as "hotspots," these essential residues are ...

Motivation: Proteins play a fundamental role in every process within the cell. Understanding how proteins interact, and the functional units they are part of, is important to furthering our knowledge of the entire biological process. There has been a growing amount of work, both experimetal and computational, on determining the protein-protein interaction network. Recently researchers have had ...

Selective chemical reactions enacted within a cellular environment can be powerful tools for elucidating biological processes or engineering novel interactions. A chemical transformation that permits the selective formation of covalent adducts among richly functionalized biopolymers within a cellular context is presented. A ligation modeled after the Staudinger reaction forms an amide bond by c...

Image diagnosis is the task in which a physician searches for abnormal findings on the medical images that potentially involve a large amount of anatomical and pathological information, and identifies diseases from such findings. Since this task aims to reduce the risk (e.g., insult or death) that will occur in the near future, it can be seen as a case of chance discoveries. To investigate the ...

Clinicians learn step by step how to apply the therapy techniques and to select the appropriate therapy materials (described in detail in practical appendices). The book also provides practical advice about dealing with group processes and individual dyadic situations. Differential indications, assessment, therapy planning and evaluation are presented. Therapists will also learn how to use IPT ...

Clinicians learn step by step how to apply the therapy techniques and to select the appropriate therapy materials (described in detail in practical appendices). The book also provides practical advice about dealing with group processes and individual dyadic situations. Differential indications, assessment, therapy planning and evaluation are presented. Therapists will also learn how to use IPT ...

Predictive methods for the computational design of proteins search for amino acid sequences adopting desired structures that perform specific functions. Typically, design of 'function' is formulated as engineering new and altered binding activities into proteins. Progress in the design of functional protein-protein interactions is directed toward engineering proteins to precisely control biolog...