GENERAL CONSIDERATIONS..................................................................... 72 VIRAL INTERFERENCE ......................................................................... 74 NATURE OF INTERFERON ....................................................................... 75 ENDOGENOUS PRODUCTION OF INTERFERON BY LETHALLY INFECTED CELLS......................... 76 ENDOGENOUS INTERFER...

Several interferon inducers (Newcastle disease virus, statolon, and poly rI:poly rC) as well as exogenous mouse interferon protect mice from sporozoite-induced Plasmodium berghei malaria, as long as they are administered before the end of the preerythrocytic phase of development of the parasite. The protective effect of the interferon inducers was related to their interferon-inducing effect; th...

Rabbit kidney cell cultures stimulated with either double-stranded polyinosinate-polycytidylate (poly I:poly C) or with ultraviolet-irradiated Newcastle disease virus (UV-NDV) produce two types of interferon response, designated "early" and "late," respectively. The early response is suppressed by inhibitors of RNA or protein synthesis and is therefore thought to represent de novo synthesis of ...

Human beta-interferon stimulates a 4-fold increase in the concentration of diacyglycerol and a 2-fold increase in the concentration of inositol monophosphate in Daudi (human B-lymphoblastoid) cells within 30 sec of exposure of the cells to interferon. The increase in diacylglycerol and in inositol monophosphate is transient and the concentrations of these compounds decrease to basal levels with...

Large-scale production of crude high-titered (10(2.3) to 10(4) U/ml) human immune interferon (type II) was carried out in roller bottle cultures of human peripheral lymphocytes by using the T-cell mitogen staphylococcal enterotoxin A. Over 99% of human immune interferon was destroyed by pH 2 or heat at 56 degrees C for 1 h. The interferon was not neutralized by antibody to human leukocyte inter...

background: creating autoantibodies against thyroid in hepatitis c patients who are being treated with interferon is now recognized for several years. recently, some studies have claimed that prevalence of autoimmune thyroid disorders in hepatitis c patients is higher when they are not treated by interferon and/or at the beginning of diagnosis, however the area still remained controversial. in ...

background: statins, widely used cholesterol-lowering agents, have also been demonstrated to have anti-inflammatory and immunomdulatory effects. objective: to evaluate the effects of atorvastatin in combination with interferon-β in the treatment of multiple sclerosis (ms) in a randomized controlled clinical trial. methods: multiple sclerosis patients were randomized independently, in a double b...

celiac disease is characterized by a gluten-induced damage of the small bowel in sensitive individuals that may cause malabsorption. non-intestinal inflammatory diseases may trigger immunologic gluten intolerance in susceptible people and the hcv virus may be considered as a suitable candidate. interferon therapy could precipitate symptom onset in subjects with silent celiac disease. in fact, s...

Recent advances in the treatment of hepatitis C virus (HCV) infection have led to the availability of both highly efficacious interferon-containing and interferon-sparing regimens. However, the use of such therapies faces restrictions due to high costs. For patients who are medically eligible to receive interferon, the choice between the two will likely be impacted by preferences surrounding in...

Antiviral potential and stability analysis of chicken interferon-? produced by Newcastle disease virus in embryo fibroblast cells | FR Anjum, SU Rahman, MA Aslam, AS Qureshi Agricultural Journals