A group of regioisomeric 5-oxo-1,4,5,6,7,8 hexahydroquinoline derivatives possessing a COX-2 SO2Me pharmacophore at the para position of the C-2 or C-4 phenyl ring, in conjunction with a C-4 or C-2 phenyl (4-H) or substituted-phenyl ring (4-F,4-Cl,4-Br,4-OMe,4-Me, 4-NO2), were designed for evaluation as selective cyclooxygenase-2 (COX-2) inhibitors. These target 5-oxo-1,4,5,6,7,8 hexahydroquino...

Let $ { mathcal{R}} L$ be the ring of real-valued continuous functions on a frame $L$ as the pointfree  version of $C(X)$, the ring of all real-valued continuous functions on a topological space $X$. Since $C_c(X)$ is the largest subring of $C(X)$ whose elements have countable image, this motivates us to present the pointfree  version of $C_c(X).$The main aim of this paper is to present t...

Two series of new soluble conjugated compounds containing tetrazine central ring have been synthesized. The three-ring compounds have been synthesized by the reaction of aryl cyanide (where aryl = thienyl, alkylthienyl, phenyl or pyridyl) with hydrazine followed by oxidation of the intermediate product with diethyl azodicarboxylate. The five-ring compounds have been prepared using two pathways:...

Photochemical pericyclic reactions are believed to proceed via a so-called pericyclic minimum on the lowest excited potential surface (S(1)), which is common to both the forward and backward reactions. Such a common intermediate has never been directly detected. The photointerconversion of 1,3-butadiene and cyclobutene is the prevailing prototype for such reactions, yet only diene ring closure ...

Although solution-plasma processing enables room-temperature synthesis of nanocarbons, the underlying mechanisms are not well understood. We investigated the routes of solution-plasma-induced nanocarbon formation from hexane, hexadecane, cyclohexane, and benzene. The synthesis rate from benzene was the highest. However, the nanocarbons from linear molecules were more crystalline than those from...

Previously, we hypothesized that hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX) can be biotransformed by anaerobic sludge via three different routes: (1) direct ring cleavage via alpha-hydroxylation of a-CH(2) group, (2) reduction of one of the -NO(2) groups to -NO, (3) N-denitration prior to ring cleavage. The present study describes biotransformation of RDX via route 3 by a diaphorase (EC 1.8....

Abstract Host–guest materials exhibit great potential applications as an insensitive high-energy–density explosive and low characteristic signal solid propellant. To investigate the mechanism of improvement energy host–guest explosives by guest molecules, ReaxFF-lg reactive molecular dynamics simulations were performed to calculate thermal decomposition reactions systems ICM-102/HNO 3 , ICM-102...

A ring $R$ with identity is called ``clean'' if $~$for every element $ain R$, there exist an idempotent $e$ and a unit $u$ in $R$ such that $a=u+e$. Let $C(R)$ denote the center of a ring $R$ and $g(x)$ be a polynomial in $C(R)[x]$. An element $rin R$ is called ``g(x)-clean'' if $r=u+s$ where $g(s)=0$ and $u$ is a unit of $R$ and, $R$ is $g(x)$-clean if every element is $g(x)$-clean. In this pa...