Carcinoma of the external auditory canal (EAC) is an unusual head and neck malignancy. The pathophysiology of these tumors is different from other skin lesions because of their anatomical and functional characteristics. Early-stage carcinoma of the EAC can be generally cured by surgical treatment, and reconstruction of the EAC with a tympanoplasty can help to retain hearing, thus improving the ...

A limited clinical trial on split-thickness skin graft donor sites was conducted in 15 consecutive patients to assess the action of MEBO compared with the conventional Sofra-Tulle (Roussel Laboratories Ltd., Uxbridge, UK) split-thickness skin graft donor site dressing used in our service. All patients included in the study were white, with Fitzpatrick skin types II and III (age range, 5–65 year...

Wide resection of malignant skin tumors in the upper orbital region often results in soft-tissue defects involving the eyebrow. We used composite skin grafts from the area around the sideburns for 1-stage reconstruction of skin and eyebrow defects. The results were aesthetically satisfying because the hair and shape of these regions were similar to those of the original eyebrow, and donor-site ...

Epidermolysis bullosa (EB) is a progressive familial disorder composed of dermal mucosal blisters, flexion contractures and pseudosyndactylies. Flexion contractures and pseudosyndactyly can be treated with surgery but usually require skin grafting. Because of poor wound healing, skin graft harvesting is a challenge in these patients. In order to prevent donor-site morbidities due to skin graft ...

A considerable array of evidence has been secured to suggest that the tempo and intensity of the host's immune response to tissue transplants are conditioned by the degree of histocompatibility existing between the individuals studied (1-4). Although this subject has received a great deal of attention in animal species, it has not been studied extensively in man (5-7). The present report is con...

Treatment of C57BL/6 mice with one transfusion of BALB/c spleen cells and anti-CD154 (anti–CD40-ligand) antibody permits BALB/c islet grafts to survive indefinitely and BALB/c skin grafts to survive for z 50 d without further intervention. The protocol induces long-term allograft survival, but the mechanism is unknown. We now report: ( a ) addition of thymectomy to the protocol permitted skin a...

Treatment of C57BL/6 mice with one transfusion of BALB/c spleen cells and anti-CD154 (anti-CD40-ligand) antibody permits BALB/c islet grafts to survive indefinitely and BALB/c skin grafts to survive for approximately 50 d without further intervention. The protocol induces long-term allograft survival, but the mechanism is unknown. We now report: (a) addition of thymectomy to the protocol permit...

Treatment of C57BL/6 mice with one transfusion of BALB/c spleen cells and anti-CD154 (anti–CD40-ligand) antibody permits BALB/c islet grafts to survive indefinitely and BALB/c skin grafts to survive for z 50 d without further intervention. The protocol induces long-term allograft survival, but the mechanism is unknown. We now report: ( a ) addition of thymectomy to the protocol permitted skin a...

Acquired tolerance to CBA skin homografts is lost in a large number of C3H mice neonatally injected with CBA spleen cells. The skin homografts persist for at least 2 months but then exhibit a chronic rejection pattern which may last up to 7 months. Histological analysis of the lymphoid tissues reveals the onset of an immune response in the axillary lymph nodes of many 4-month-old tolerant mice....

the purpose of this study was the utilization of different methods of tissue culture in proliferation of epithelial cells and autologous graft to cover surface areas without skin specifically, which is due to thermal burns more than 50%. in this experience we performed from rabbits and success to cover almost 24 times original donor site with autograft.