OBJECTIVE To compare the safety profiles of intracameral cephalosporins in cataract surgery. PATIENTS AND METHODS In this controlled trial, 129 patients were randomized to one of four groups to receive 1 mg of one of three cephalosporins - cefazolin, cefuroxime, or ceftazidime, or normal saline - given intracamerally during cataract surgery. Central endothelial cell density (ECD) and retinal ...

PURPOSE To determine the safety of prophylactic intracameral moxifloxacin 0.5% ophthalmic solution (Vigamox) in patients having cataract surgery. SETTING American Eye Center, Manila, Philippines. METHODS Preoperative and 1-month postoperative anterior chamber reaction, corneal endothelial cell density, and corneal thickness were assessed in 65 eyes that had cataract surgery with intracamera...

Postoperative endophthalmitis is one of the most serious potential complications of ocular lens surgery. Its incidence can be reduced by means of antibiotic prophylaxis. Although the prophylactic use of intracameral cefuroxime has been extended, other drugs, such as moxifloxacin, have arisen as alternatives. We performed a systematic literature review on the effectiveness and efficiency of intr...

The familiar dictum ‘‘First, do no harm’’ is particularly applicable in the setting of intracameral medications in cataract and anterior segment surgery. Intracameral medication has multiple potential uses in these surgical procedures, including pupil dilation, anesthesia, and prevention of endophthalmitis/inflammation. Its advantages and disadvantages were highlighted in the ‘‘Spotlight on Cat...

Ocular iris metastasis from lung cancer is uncommon. We report a patient with metastatic non-small cell lung cancer who was found to have a metastatic lesion to the iris. Local therapy for pain control and vision loss was administered with intracameral bevacizumab. Complete resolution of pain, improvement in vision, and near complete resolution of iris tumor were seen within two months. No ocul...

Brinzolamide is a topical carbonic anhydrase inhibitor which reduces the production of aqueous humor in ciliary body, thereby reducing intra-ocular pressure. It formulated as an ophthalmic suspension. The pharmacokinetics ocular suspensions not well understood. objective this study was to characterize brinzolamide rabbit humor, iris-ciliary plasma, and whole blood. New Zealand White rabbits wer...