Intracranial hypotension increases cerebral blood flow. In dogs the average increase in cortical blood flow was 30 ml./100 g/min (47%) when the intracranial pressure was lowered acutely from 100 to 40 mm CSF. Permanent intracranial hypotension was established in seven demented patients using a ventriculoatrial shunt. The mean post shunt pressure was 50 mm CSF. In this group, the cerebral vascul...

The effect of intra-arterial sodium nitroprusside infusions on acute experimental basilar artery spasm was studied in dogs. Vasospasm produced by subarachnoid hemorrhage at normal intracranial pressure was partially relieved by nitroprusside. When given by the intra-arterial route, 15 times the recommended maximum intravenous does can be infused without significant hypotension or elevation in i...

The syndrome of spontaneous intracranial hypotension is characterised by postural headache, low CSF pressure, and MRI findings of diVuse pachymeningeal gadolinium enhancement without a history of head or back trauma or lumbar puncture. We report on the MRI findings of a patient with spontaneous intracranial hypotension, before and after treatment. A 44 year old woman presented with severe subac...

BACKGROUND AND PURPOSE CT myelography has historically been the test of choice for localization of CSF fistula in patients with spontaneous intracranial hypotension. This study evaluates the additional benefits of intrathecal gadolinium MR myelography in the detection of CSF leak. MATERIALS AND METHODS We performed a retrospective review of patients with spontaneous intracranial hypotension w...

BACKGROUND AND PURPOSE Spontaneous intracranial hypotension can be a therapeutic challenge to the treating physician. In this study, we present our experience with the administration of a large-volume blood patch to multiple sites in the epidural space through a single-catheter access site. MATERIALS AND METHODS A retrospective review was conducted of patients with spontaneous intracranial hy...