Several procedures have been utilized to elevate plasma free fatty acid (FFA) concentration and increase fatty acid (FA) delivery to skeletal muscle during exercise. These include fasting, caffeine ingestion, L-carnitine supplementation, ingestion of medium-chain and long-chain triglyceride (LCT) solutions, and intravenous infusion of intralipid emulsions. Studies in which both untrained and we...

VVe inyestigated the effects of oolong tea ofi the basic metabolism of plasma lipids in mice under restraint stress. When a lipid emulsion (Intralipid 20%; a lipid emulsion containing 20% soybean oil) wus iajected intravenously into mice, the restraint stress prolonged the half-life CTm) of elimination for plasma triglyceride (TG) from 28.7 to 55.5 min. The elimination rate per minllte was 48.2...

An experimental and clinical study on DI-22, a fat emulsion for intravenous use and the first such product to be developed in Japan is present. DI-22 consists of linoleic acid, oleic acid, palmitic acid and linoleic acid which is made isotonic with glycerol. The size of the fat particles are 0.8-1.0 in diameter and are uniform in shape. The fluctuation of hemoglobin and hematocrit was the same ...

Dermal microdialysis was used to assess the bioavailability of a topical corticosteroid, clobetasol propionate, following application onto the skin of human subjects. The penetration of clobetasol propionate from a 4% m/v ethanolic solution applied onto 4 sites on one forearm of healthy human volunteers was studied. A lipid emulsion, Intralipid®, was used as the perfusate and linear microdialys...

A new proposal for spinal cord and brain treatment and protection due to injuries and diseases is made herein. It is composed of two 20G nylon catheters with 6 lateral holes arranged circumferentially within 3 cm from the tip and a closed end. One catheter is inserted into the epidural space and the other catheter is inserted into the spinal space in two different lumbar interspaces using an 18...

The emulsion formulation of propofol (Diprivan) evokes pain on i.v. injection, although its pH and osmolality are close to those of blood. The pain induced by serial dilutions of propofol in Intralipid and 5% glucose was examined in isolated vein segments and after intracutaneous injection. Propofol evoked pain in a concentration-related manner in six of eight subjects after i.v. perfusion and ...

Recurrent spontaneous miscarriage (RSM), defined as ≥2 clinically detectable pregnancy losses before 20 weeks of gestation with the same partner. Many studies have been suggested abnormal natural killer (NK) cell activity can be a high chance division linked with RSM. Aberrant expression of angiogenic cytokines during implantation window in women with RSA is one of the key factors that adversel...