Key words neutral homoaromatics - intramolecular Buchner reaction dearomatization photoswitch

Social bonds are necessary for many mammals to survive and reproduce successfully. These bonds (i.e. pair-bonds, friendships, filial bonds) are characterized by different periods of development, longevity and strength. Socially monogamous species display certain behaviors not seen in many other mammals, such as adult pair-bonding and male parenting. In our studies of prairie voles (Microtus och...

Chitin is one of the most common polysaccharides and abundant in cell walls fungi shells insects aquatic organisms as a skeleton. The mechanism how chitin responds to pH essential precise control brewing design smart materials. However, this molecular remains mystery. Results from single-molecule studies, including force spectroscopy (SMFS), AFM imaging, dynamic (MD) simulations, have shown tha...

an efficient three-component reaction of dialkyl acetylendicarboxylates and 2-pyrrolidin in the presence of triphenylphosphine produces dialkyl 2-(2-pyrrolidin-n-yl)-3-(triphenylphosphanylidene)succinate. these phosphoranes undergo mild intramolecular wittig reaction to produce dialkyl (e)-2-(4,5-dihydro-3h-pyrrol-2-yl)fumarate in excellent yields.

Removal of the C-terminal seven residues from phosphoglycerate mutase from Saccharomyces cerevisiae by limited proteolysis is associated with loss of mutase activity, but no change in phosphatase activity. The presence of the cofactor 2, 3-bisphosphoglycerate, or of the cofactor and substrate 3-phosphoglycerate together, confers protection against proteolysis. The substrate alone offers no prot...

Sweep frequency ultrasound- (SFU-) assisted alkali extraction was conducted to increase the yield and content of heat-sensitive protein walnut meal under a relatively mild condition. The physicochemical structural characteristics proteins obtained by SFU-assisted conventional were compared. It found that optimal parameters for solid-liquid ratio 1 : 12, pH value 9, initial temperature 25°C, ult...

The dynamic interplay between the intramolecular hydrogen bonding and intramolecular vibrational redistribution is found to be critical in nonadiabatic reaction dynamics. Herein, it has been demonstrated that the molecular planarity, directed by the intramolecular hydrogen bonding, plays an important role in the nonadiabatic passage of the reactive flux at the conical intersection in the photod...

(1)H NMR chemical shifts have been obtained in the solvents deuterochloroform and dimethyl sulfoxide. The difference in the chemical shifts of an OH or NH group in these two solvents, Δδ = δ(DMSO) - δ(CDCl3), can be converted into the hydrogen bond acidity, A, of the group using the equation A = 0.0065 + 0.133Δδ. The NMR A value, ANMR, can be used as a quantitative assessment of intramolecular ...

Strategies for high-throughput analysis of interactions between various hormones and drugs with the estrogen receptor (ER) are crucial for accelerating the understanding of ER biology and pharmacology. Through careful analyses of the crystal structures of the human ER (hER) ligand-binding domain (hER-LBD) in complex with different ligands, we hypothesized that the hER-LBD intramolecular folding...