Selective alkylation of a chosen sequence of DNA typically relies on ligand-directed delivery of a compound that expresses an intrinsic reactivity. A significant and biologically relevant enhancement in specificity is theoretically possible if such an intrinsic reactivity could be replaced by a latent activity induced solely by the target of interest, but examples of this are rare and not easil...

Photo-catalyzed tandem dearomatization/carboxylation of benzyl o-halogenated aryl ether with CO2 was achieved, which affords spirocyclic carboxylic acids under mild conditions. The reaction has good functional group tolerance high yields. Mechanism studies indicate that the transformation realized via intramolecular radical addition and nucleophilic addition.

A transition-metal-free direct electrolytic C?H amination involving an electrochemically generated nitrenium ion intermediate has been developed. The electrosynthesis takes place in the absence of any organoiodine catalysts and is enabled by situ electrolyte. novel, efficient intramolecular intermolecular demonstrated using a simple reaction setup.