BACKGROUND/AIMS To evaluate the efficacy and safety of propofol and midazolam for sedation during esophagogastroduodenoscopy (EGD) in children. METHODS We retrospectively reviewed the hospital records of 62 children who underwent ambulatory diagnostic EGD during 1-year period. Data were collected from 34 consecutive patients receiving propofol alone. Twenty-eight consecutive patients who rece...

The problem of sedation and analgesia for ventilator-dependent patients was examined in this study. Twenty subjects undergoing elective coronary revascularization surgery at a major medical center were studied. They ranged in age from 49 to 83 years. A randomized, prospective research design was used to place subjects in either an experimental group or a control group. Standard postoperative an...

PURPOSE The purpose of this investigation was to compare the pharmacokinetics of midazolam following intravenous, intranasal drop, and nasal-atomizer administration in beagle dogs. METHODS Six animals weighing 9-13 kg were used in a repeated-measure design, group assignment based on route of drug administration. Midazolam (1.5 mg/kg) was administered with the delivery route based on group ass...

A 6-year-old boy was scheduled for thoracic magnetic resonance imaging under deep sedation with midazolam 1.8 mg and propofol 100 µg/kg/min via intravenous injection. He showed emergence delirium in the post-anesthesia care unit. The staff attempted to calm him by administering flumazenil as an antidote for midazolam, propofol for further sedation, and meperidine. However, this was not successf...

This study was undertaken to compare the induction characteristics of conventional thiopentone sodium, midazolam, and a combination of midazolam and thiopentone sodium as co-induction agent. Total one hundred and fifty patients of ASA grade I and II were divided into three groups in a double blind randomized study. Group-I received midazolam 0.25 mgkg-1 intravenously, group–II received thiopent...

BACKGROUND Midazolam is a sedative-hypnotic agent with amnestic and anticonvulsant properties that can be administrated to mammals through various routes, such as intravenous, intramuscular, oral, intrathecal, rectal, and buccal. Midazolam administration in the form of eye drops through the conjunctiva is not reported in the literature. AIM This study aims to demonstrate the possible central ...

The purpose of this study was to compare the psychomotor recovery of patients sedated with either midazolam or Diazemuls using the digit symbol substitution test and the Trieger test. Sixty patients were allocated in random double-blind fashion to receive either midazolam or diazepam in oil emulsion (Diazemuls) as intravenous sedation for cataract surgery. Both groups received fentanyl 0.5 micr...

Propofol (2,6,di-isopropylphenol) was given by continuous intravenous infusion to provide sedation after cardiac surgery in 30 patients and its effects compared with those of midazolam given to a further 30 patients. Propofol infusion allowed rapid and accurate control of the level of sedation, which was satisfactory for longer than with midazolam. Patients given propofol recovered significantl...

OBJECTIVE To determine whether treatment with midazolam or with nitrous oxide is more efficient in facilitating intravenous (IV) access in lean and obese children and adolescents. DESIGN A prospective, double-blind, randomized trial of 90 children and adolescents. SETTING Astrid Lindgrens Children's Hospital, Karolinska University Hospital, Stockholm, Sweden. Patients A total of 60 obese ch...