In life sciences, diastereomeric chiral molecule/chiral receptor complexes are held together by a different combination of intermolecular forces and are therefore endowed with different stability and reactivity. Determination of these forces, which are normally affected in the condensed phase by solvent and supramolecular interactions, can be accomplished through the generation of diastereomeri...

AC electrokinetics is a versatile tool for contact-less manipulation or characterization of cells and has been widely used for separation based on genotype translation to electrical phenotypes. Cells responses to an AC electric field result in a complex combination of electrokinetic phenomena, mainly dielectrophoresis and electrohydrodynamic forces. Human cells behaviors to AC electrokinetics r...

Quantum particles confined to surfaces in higher dimensional spaces are acted upon by forces that exist only as a result of the surface geometry and the quantum mechanical nature of the system. The dynamics are particularly rich when confinement is implemented by forces that act normal to the surface. We review this confining potential formalism applied to the confinement of a particle to an ar...

We propose an efficient method for computing coupled flow–body dynamics. The time-stepping is implicit, and uses an iterative method (preconditioned GMRES) to solve the flow–body equations. The preconditioner solves a decoupled version of the equations which involves only the inversion of banded matrices, and requires a small number of iterations per time step. We use the method to probe the in...

We present a phenomenological description of cell locomotion on a solid substrate. The material properties of the actin cytoskeleton in the lamellipodium are described by the constitutive equations of a viscous polar gel with intrinsic activity. The polymerization of the gel takes place in a localized region near the leading edge. Using a simple two-dimensional description, we calculate in the ...

Many problems in beam dynamics are concerned with calculation of the inter-particles forces for millions of particles. One particular hard example is described in this annual report, see [1]. In order to estimate the interparticle forces in the electrostatic approximation with intrinsic open boundary conditions we have naively to compute the electric field at every particle’s position by summin...

Meiotic nuclear oscillations in the fission yeast Schizosaccharomyces pombe are crucial for proper chromosome pairing and recombination. We report a mechanism of these oscillations on the basis of collective behavior of dynein motors linking the cell cortex and dynamic microtubules that extend from the spindle pole body in opposite directions. By combining quantitative live cell imaging and las...

We recently demonstrated that a set of five functional muscle synergies were sufficient to characterize both hindlimb muscle activity and active forces during automatic postural responses in cats standing at multiple postural configurations. This characterization depended critically upon the assumption that the endpoint force vector (synergy force vector) produced by the activation of each musc...

A comprehensive understanding of the control of flexible fins is fundamental to engineering underwater vehicles that perform like fish, since it is the fins that produce forces which control the fish's motion. However, little is known about the fin's sensory system or about how fish use sensory information to modulate the fin and to control propulsive forces. As part of a research program that ...

During growth and development, the skin expands to cover the growing skeleton and soft tissues by constantly responding to the intrinsic forces of underlying skeletal growth as well as to the extrinsic mechanical forces from body movements and external supports. Mechanical forces can be perceived by two types of skin receptors: (1) cellular mechanoreceptors/mechanosensors, such as the cytoskele...