C ANCER of the uterine cervix is the most common cancer among Indian women. In India, annually about 130,000 women fall prey to cervical cancer which is commonly seen among women of low socio-economic status. The factors that are known to predispose to this disease include poor genital hygiene, early marriage, multiple pregnancies and childbirth, promiscuous sexual life and chronic infection or...

To identify novel cervical cancer-related genes that are regulated by DNA methylation, integrated analyses of genome-wide DNA methylation and RNA expression profiles were performed using the normal and tumor regions of tissues from four patients; two with cervical cancer and two with pre-invasive cancer. The present study identified 19 novel cervical cancer-related genes showing differential RN...

BACKGROUND An emerging literature suggests that violence against women (VAW), particularly sexual violence, may increase the risk of acquiring a sexually transmitted infection (STI) and, therefore, may be associated with cervical cancer development. The purpose of this cross-sectional analysis was to determine if women who had experienced violence had higher prevalence rates of invasive cervica...

different ages: evidence from the UK audit of screening histories. Br J Cancer 2003; 89: 88–93. 9 Sasieni P, Castanon A, Parkin DM. How many cervical cancers are prevented by treatment of screen-detected disease in young women? Int J Cancer 2009; 124: 461–464. 10 Sigurdsson K, Sigvaldason H. Is it rational to start populationbased cervical cancer screening at or soon after age 20? Analysis of t...

Programmed cell death 4 (PDCD4) is a tumor suppressor, and it inhibits tumor progression and metastasis. Even though down-regulation of PDCD4 has been implicated with many different types of human cancers, its roles in the progression of cervical cancer remain unexplored. Here, we have systematically examined the expression pattern of PDCD4 in cervical tissues. 15 cervical normal tissues, 14 ce...

Previous studies on the associations between dietary antioxidant vitamins and the risk of cervical cancer remain inconsistent, and little evidence is available for serum antioxidant vitamins, which provide more accurate measurements of these nutrients. We conducted a case-control study of 458 incident cases with invasive cervical cancer and 742 controls to assess the effects of diet or serum an...

objective(s):eukaryotic translation initiation factor 4e (eif4e) is overexpressed in cervical cancer (cc). however, the molecular mechanisms are unclear. this study aimed to investigate the molecular mechanism of eif4e gene overexpression in cc. materials andmethods:the human papillomavirus (hpv) type 18 e7 and eif4e mrnas were measured following knock down or overexpression of e7 gene by rt-pc...

The first part of this article will provide an overview of cervical cancer screening in the UK during the years before, during and after the introduction of a highly successful centrally organised cervical screening programme in 1988: since then the incidence of invasive cervical cancer has fallen by more than 40%. Screening was introduced in a background of opportunistic screening with poor qu...

Burden of suffering It is estimated that approximately 15,000 women will be diagnosed with invasive carcinoma of the cervix and 4,800 women will die from this disease in 1995. (1) Rates for carcinoma in situ peak between the ages of 20 and 30, and the incidence of invasive cervical cancer increases with age. (2) Twenty-five percent of all invasive cervical cancers occur in women over age 65. An...