نتایج جستجو برای: invasive mole
تعداد نتایج: 165769 فیلتر نتایج به سال:
Complete hydatidiform mole (CHM) is a rare pregnancy-related disease with invasive potential. The genetics underlying the sporadic form of CHM have not been addressed previously, but maternal genetic variants may be involved in biparental CHM. We performed whole-exome sequencing of 51 patients with CHM and 47 healthy women to identify genetic variants associated with CHM. In addition, candidate...
The aim of this study is to retrospectively analyze the therapeutic effects low-risk invasive mole treatment by methotrexate and summarize high-risk factors which affect chemotherapy outcome. Collect clinical data relationship human chorionic gonadotropin levels largest tumor sizes with cycle toxicity in Zhuzhou Central Hospital from 2015 2020. In study, 42 patients were enrolled All are treate...
AIMS To compare the expression of c-myc and c-fms proto-oncogenes in the placenta and hydatidiform mole. METHODS Twelve hydatidiform moles and six induced abortion cases were collected. c-myc and c-fms proto-oncogene expression was analysed by northern blot hybridisation and immunohistochemical staining. RESULTS The results of northern blot hybridisation analysis showed that c-fms was expre...
Complete hydatidiform mole and partial hydatidiform mole are two abnormal conceptuses that may be identified by clinical, ultrasonographic, gross morphological, histological, and genetic characteristics. Among all these criteria, the specific diagnosis is generally confirmed only upon histological review. However, an accurate diagnosis based on morphological criteria is difficult and several st...
Hydatidiform moles (HMs) most often occur sporadically and are either diploid androgenetic or triploid. The very rare familial recurrent HMs (FRHMs) have been related to NLRP7 and C6orf221 mutations in the mother. FRHMs are most often diploid with both maternal and paternal origin of the molar genome. We have screened a cohort of 11 women with diploid HMs with biparental contributions to the mo...
Familial recurrent hydatidiform mole is a rare event; here we report an unusual case of a gravida 5 aged 29 years, with five recurrent hydatidiform moles and no normal pregnancy. After the fourth molar pregnancy, she developed persistent trophoblastic disease that required 7 cycles of single agent chemotherapy. Two years after the treatment, she presented with her fifth molar pregnancy. Her eld...
Gestational Trophoblastic Disease (GTD) in Latin America (LA) has a wide range of presentation and management, depending on socioeconomic, political and geographic variables [1,2,3]. Thus, while some referral centers have sophisticated methods for an early and accurate diagnosis and treatment, still there are a high number of patients admitted with a late Hydatidiform Mole (HM) or advanced Gest...
Successful laboratory tests for early pregnancy utilize the endogenous production and excretion of chorionic gonadotrophin (CG). There is wide variation in sensitivity and specificity of various biological and commercially available immunochemical methods for determining urinary CC levels. Normal values for immunochemically reactive CC during the first trimester of pregnancy are given. Serial d...
Using polymerase chain reaction and denaturating polyacrylamide gel electrophoretic techniques, we studied 53 cases of hydatidiform moles. Of these, 41 cases were genetically complete hydatidiform moles (g-CHM) whose genome were totally paternally derived. We investigated the distribution of the alleles in the short tandem repeat sequences at loci D16S539, D7S820, and D13S317 in these cases. In...
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