The ionizable groups and conductances of the rod plasma membrane were studied by measuring membrane potential and input impedance with micropipettes that were placed in the rod outer segments. Reduction of the pH from 8.0 to 6.8 or from 7.8 to 7.3 resulted in membrane depolarization in the dark from 8.0 to 6.8 or from 7.8 to 7.3 resulted in membrane depolarization in the dark (by 2- 3 mV) and a...

A B ST R A C T The ionizable groups and conductances of the rod plasma membrane were studied by measuring membrane potential and input impedance with micropipettes that were placed in the rod outer segments. Reduction of the pH from 8.0 to 6.8 or from 7.8 to 7.3 resulted in membrane depolarization in the dark (by 2-3 mV) and an increased size of the light response (also by 2-3 mV). The dark dep...

A B ST R A C T The ionizable groups and conductances of the rod plasma membrane were studied by measuring membrane potential and input impedance with micropipettes that were placed in the rod outer segments. Reduction of the pH from 8.0 to 6.8 or from 7.8 to 7.3 resulted in membrane depolarization in the dark (by 2-3 mV) and an increased size of the light response (also by 2-3 mV). The dark dep...

The role of electrostatic interactions in the separation of pharmaceuticals by a loose nanofiltration (NF) membrane was examined. While retention of the non-ionizable pharmaceutical carbamazepine was relatively independent of the solution chemistry, retention of the ionizable pharmaceuticals sulfamethoxazole and ibuprofen was strongly influenced by the solution pH and ionic strength. This findi...