Insulin receptor substrate (IRS) molecules are key mediators in insulin signaling and play a central role in maintaining basic cellular functions such as growth, survival, and metabolism. They act as docking proteins between the insulin receptor and a complex network of intracellular signaling molecules containing Src homology 2 (SH2) domains. Four members (IRS-1, IRS-2, IRS-3, IRS-4) of this f...

D-glucose regulates maintenance and function of pancreatic beta-cells. Several studies have shown that IRS-2, but not IRS-1, is necessary to maintain and sufficient to expand functional beta-cell mass. We therefore analyzed the expression of IRS-2 and IRS-1 in beta-cells after culture in the presence of various concentrations of D-glucose and other metabolisable or non-metabolisable hexoses. D-...

a r t i c l e i n f o Remote sensing can be considered a key instrument for studies related to forests and their dynamics. At present, the increasing availability of multisensor acquisitions over the same areas, offers the possibility to combine data from different sensors (e.g., optical, RADAR, LiDAR). This paper presents an analysis on the fusion of airborne LiDAR and satellite multispectral ...

there have been different indices identified for desertification. among these is technogenic desertification index which seems much more efficient. in this study, some of technogenic desertification indices were studied and evaluated. first land use maps of the region were taken from irs-pan satellite image and aerial photos analysis. after evaluating the area of different uses, lands that had ...

soil salinity has been a large problem in arid and semi arid regions. preparation of such maps is useful for natural resource managers. old methods of preparing such maps require a lot of time and cost. multi-spectral remotely sensed dates due to the broad vision and repeating of these imageries is suitable for provide saline soil maps. this investigation is conducted to provide saline soil map...

there have been different indices identified for desertification. among these is technogenic desertification index which seems much more efficient. in this study, some of technogenic desertification indices were studied and evaluated. first land use maps of the region were taken from irs-pan satellite image and aerial photos analysis. after evaluating the area of different uses, lands that had ...

during the time, land cover and as a result land use patterns go through fundamental changes and human factors can have the most important role in this process. knowing these changes could be of great help to the future management of this region. according to this, the main purpose of this study is to monitor the land use-cover changes in the hamedan province area during the three recent decade...

Insulin receptor substrate 1 (IRS-1), and its structural relative IRS-2, are both phosphorylated on tyrosine following treatment of cells with interleukin-4 (IL-4) and insulin. We have investigated whether both IRS-1 and IRS-2 are expressed in murine lymphohemopoietic cells. T and B lymphocytes and macrophages from primary cultures expressed only IRS-2, which became phosphorylated on tyrosine f...

To examine the impact of homozygous genetic disruption of IRS-1 (IRS-1-/-) or IRS-2 (IRS-2-/-) on basal and insulin stimulated carbohydrate and lipid metabolism in vivo we infused 18-h fasted mice (WT, IRS1-/and IRS2-/-) with [3-3H]glucose and [H5]glycerol and assessed rates of glucose and glycerol turnover under basal (0-90 min) and hyperinsulinemic-euglycemic clamp (90-210 min; 5 mM glucose a...

BACKGROUND Indoor residual spraying (IRS) for malaria prevention has traditionally been implemented in Ethiopia by the district health office with technical and operational inputs from regional, zonal, and central health offices. The United States President's Malaria Initiative (PMI) in collaboration with the Government of Ethiopia tested the effectiveness and efficiency of integrating IRS into...