Neutrophil adherence and/or aggregation has been implicated in ischemia reperfusion injuries. We examined the role of P-selectin in PMN-mediated injury after reperfusion of the rabbit ear. The ear was partially amputated, and then reattached leaving the central artery and vein intact. To induce ischemia the central artery was then occluded. Treatment was at reperfusion with either saline or one...

1. Divisão de Pneumologia, Instituto do Coração – InCor – Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo, São Paulo (SP) Brasil. 2. Unidade de Terapia Intensiva, A.C.Camargo Cancer Center, São Paulo (SP) Brasil. The pulmonary parenchyma is prone to injuries caused by indirect insults, such as sepsis, pancreatitis, burn, blood transfusion, bypass surgery, intoxication, a...

renal ischemia-reperfusion (ir) injury is a common problem in kidney transplantation. there is increasing evidence about the role of the reactive oxygen species (ros) in these injuries and endogenous antioxidants seem to have an important role in decreasing the renal tissue injury. the aim of this study was to investigate the effects of kidney ir on renal antioxidant enzymes activity such as ca...

background: it is well known that the hippocampus, the ca1 pyramidal cells in particular, is selectively vulnerable during global cerebral ischemia. recently, it is observed that pentoxifylline has a neuroprotective effect. this study explored the pharmacological relationship between ischemia-induced cell death of the hippocampus and the efficacy of a vasodilator agent (pentoxifylline) in the p...

BACKGROUND We recently demonstrated that the sarcolemmal ATP-sensitive potassium (sarcK(ATP)) channel plays a key role in cardioprotection against ischemia/reperfusion injuries in Kir6.2-knockout (KO) mice. In the present study, we evaluated the effects of diazoxide, a mitochondrial ATP-sensitive potassium (mitoK(ATP)) channel opener, on ischemia-induced myocardial stunning in sarcK(ATP) channe...

tetracyclines are broad spectrum antibiotics which are inexpensive and widely available and have an appropriate safety profile. in addition to antibiotical effects, tetracyclines can inhibit matrix metaloproteinase and collagenase, and subsequently reduce inflammation, angiogenesis, and neovascularization. they have partial neuro-protective, anti-apoptotic and antioxidant properties. given thes...

Positron emission tomography (PET) is a non-invasive nuclear imaging technique that uses radiotracers to track cell activity. The radiopharmaceutical 18F-fluoro-2-deoxyglucose ([18F] FDG) most commonly used in medicine for the diagnosis of various diseases, including stroke. A stroke serious condition with high mortality and morbidity rates. Rosmarinic acid (RA) promising therapeutic agent exer...

PURPOSE To evaluate intestinal inflammatory and apoptotic processes after intestinal ischemia/reperfusion injury, modulated by pentoxifylline and hypertonic saline. METHODS It was allocated into four groups (n=6), 24 male Wistar rats (200 to 250 g) and submitted to intestinal ischemia for 40 min and reperfusion for 80 min: IR (did not receive any treatment); HS group (Hypertonic Saline, 4 ml/...

renal ischemia-reperfusion (ir) contributes to the development of acute renal failure (arf). oxygen free radicals are considered to be principal components involved in the pathophysiological tissue alterations observed during renal ir. the purpose of this study was to investigate the combination effect of melatonin (mel) and erythropoietin (epo), which are a potent antioxidant and anti-apoptoti...