In many cases, acute renal failure (ARF) is the result of proximal tubular cell injury and death and can arise in a variety of clinical situations, especially following renal ischemia and drug or toxicant exposure. Although much research has focused on the cellular events leading to ARF, less emphasis has been placed on the mechanisms of renal cell repair and regeneration, although ARF is rever...

Cardiolipin (CL) is a phospholipid predominantly found in the mitochondrial inner membrane and associated structurally with individual complexes of the electron transport chain (ETC). Since the ETC is the major mitochondrial reactive oxygen species (ROS) generating site, the proximity to the ETC and bisallylic methylenes of the polyunsaturated fatty acid chains of CL make it a likely target of ...