Abstract RNA splicing, and variations in this process referred to as alternative are critical aspects of gene regulation eukaryotes. From environmental responses plants being a primary link between genetic variation disease humans, splicing differences confer extensive phenotypic changes across diverse organisms (1–3). Regulation occurs through differential selection splice sites reaction, whic...

CD44, a cell surface proteoglycan, is involved in multiple biological events. CD44 transcripts undergo tissue-dependent alternative splicing, resulting dozens of functionally distinct isoforms. However, the nature these isoforms human skin has not been adequately determined. Recently, we isolated and designated all 18 unique by cloning strategy. In our previous study, found that expression tran...

Abstract Objectives Aside from the activity of gaseous transmitter molecule nitric oxide (NO) and cyclic GMP producing enzyme soluble guanylyl cyclase (sGC) in human penile erectile tissue, intracellular receptor proteins activated by binding have been considered to play a significant role erection process. In animal models, down-regulation GMP-dependent/binding protein kinase I (cGKI) has link...

There is increasing evidence to indicate that insulin‑like growth factor (IGF)‑1 plays a crucial role in the regeneration of different tissues following injury. Notably, despite escalating number animal studies, studies investigating IGF‑1 wound healing process humans are fewer. In this context, aim present study was evaluate variations expression isoforms (IGF1‑Ea, IGF1‑Eb and IGF1‑Ec), as wel...