Chiral recognition of protein-binding sites by a simple organic molecule with selectivities >100 is reported here. The l-isomer of 4(1-pyrene)-3-butyroyl-phenylalanine amide (Py-L-Phe) binds to BSA with an affinity constant (K(b)) of 3 x 10(7) M(-1), whereas the corresponding D-isomer (Py-D-Phe) binds 100 times weaker. The enantiomers showed contrasting spectral changes when bound to BSA. Where...

The enantioselective binding of the (SSS)-Δ isomer of an yttrium(III) tetraazatriphenylene complex to 'drug-site II' of human serum albumin (HSA) was detected by the intensity differences of its STD (1)H NMR spectrum relative to the (RRR)-Λ isomer, by the effect of the competitive binder to that site, N-dansyl sarcosine, upon the STD spectrum of each isomer, in the presence of HSA and by 3D doc...

Thiosemicarbazones possessing electron-donating and electron-withdrawing groups were prepared, and their spectral characteristics determined. In all cases, the spectra showed that one isomer was formed, allowing further functionalization to molecules of biological interest. We provide NMR data for some of the thiosemicarbazones and semicarbazones. We also provide evidence that for 2-pyridyl thi...

Recently the CO4 isomer with C2v symmetry has been detected in an experiment [C. S. Jamieson et al., Chem. Phys. Lett. 440, 105 (2007)]. To further characterize this isomer, we report its optical excitation and absorption spectra calculated by the time-dependent density functional theory. Its rich spectral features are compared with those of another stable isomer having D2d symmetry. Their spec...

also had found an antifibrinolytically active isomer of AMCHA , but they reserved in deciding its molecular shape. In fact , it seemed that their results tempted them to regard the active isomer as a cis-form . instead of tra.ns-form Accordingly, the authors understand that the antifibrinolytic activity of trans-AMCHA was claimed solely by our group . The active isomer belonging to trans-form w...

Abstract The available data on the even–even isotope 174 Hf are reinterpreted to conclude that low-lying 0 2 + level, usually regarded as a “β vibration”, is actually proton (2p–2 h) excitation known Pairing Isomer. This first identification of Isomer based Proton Nilsson Orbitals. Its demonstrates Isomers can exist anywhere in Nuclear Chart if positioning Fermi Surface favourable with respect ...

Oxidation of a doubly cyclometallated platinum(II) complex results in two isomeric platinum(IV) complexes. Whereas the trans isomer is robust, being manipulable in air at room temperature, the cis isomer decomposes at -20 °C and above. Reductive coupling of an alkyl chloride at the cis isomer gives a new species which can be reoxidised. The independence of this coupling on additional halide rul...

Dibenzoylketene 5 undergoes degenerate 1,3-shifts of the phenyl group between acyl and ketene carbon atoms, thus interconverting it with 6 and 7. This 1,3-shift takes place in the gas phase under flash vacuum thermolysis (FVT) conditions, but not in solution at 110-145 degrees C. Imidoyl(benzoyl)ketene 13 undergoes degenerate 1,3-shift of the phenyl group on FVT, thus interconverting it with 14...