نتایج جستجو برای: isoprostanes
تعداد نتایج: 1092 فیلتر نتایج به سال:
This study tested the hypothesis that angiotensin promotes oxidative stress and inflammation in humans via aldosterone and the mineralocorticoid receptor. We measured the effect of intravenous aldosterone (0.7 g/kg per hour for 10 hours followed by 0.9 g/kg per hour for 4 hours) and vehicle in a randomized, double-blind crossover study in 11 sodium-restricted normotensive subjects. Aldosterone ...
We examined the effects of several E-ring and F-ring isoprostanes on mechanical and electrophysiological activity in porcine coronary artery. Several isoprostanes evoked concentration-dependent contractions, with 8-iso-PGE2 being the most potent (-log EC50 of 6.9 +/- 0.1); this excitatory effect has been described in detail elsewhere and was not examined further here. 8-iso-PGE2 evoked dose-dep...
BACKGROUND Excess adiposity is associated with greater systemic inflammation. Whether visceral adiposity is more proinflammatory than subcutaneous abdominal adiposity is unclear. METHODS AND RESULTS We examined the relations of abdominal subcutaneous adipose tissue (SAT) and visceral adipose tissue (VAT), assessed by multidetector computerized tomography, to circulating inflammatory and oxida...
BACKGROUND Cardiopulmonary bypass (CPB) lyses erythrocytes and induces lipid peroxidation, indicated by increasing plasma concentrations of free hemoglobin, F2-isoprostanes, and isofurans. Acetaminophen attenuates hemeprotein-mediated lipid peroxidation, reduces plasma and urine concentrations of F2-isoprostanes, and preserves kidney function in an animal model of rhabdomyolysis. Acetaminophen ...
Glycemic load is associated with oxidative stress among prevalent maintenance hemodialysis patients.
BACKGROUND High glycemic index (GI) and glycemic load (GL) are associated with increased levels of oxidative stress and systemic inflammation in the general population. Maintenance hemodialysis (MHD) patients are known to have excessive oxidative stress burden and inflammation. In this study, we examined the relationship between dietary GI or GL and markers of oxidative stress or inflammation a...
Pregnant women are under the risk of developing pre-eclampsia. Some studies indicate that women with pre-eclampsia have higher values of isoprostanes, which includes α -and γ -tocopherol, compared to women without pre-eclampsia. To be able to predict whether the pregnant women have the danger of pre-eclampsia or not, it is important to know the normal values of α -and γ -tocopherol. In my paper...
RESEARCH DESIGN AND METHODS—The PPAR agonist (10 mg o.d. GW501516), a comparator PPAR agonist (20 g o.d. GW590735), and placebo were given in a double-blind, randomized, three-parallel group, 2-week study to six healthy moderately overweight subjects in each group. Metabolic evaluation was made before and after treatment including liver fat quantification, fasting blood samples, a 6-h meal tole...
See article by Wilson et al. [9] (pages 601 –607) in this attenuated by pretreatment with L-arginine or the NO issue. donor NOR-3. These observations suggest a tonic vasoconstrictor activity dynamically opposed by NO, with the net vasomotor effect resulting from the balance of the two
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