OBJECTIVE [corrected] To estimate the association between passive and active smoking exposures and lung cancer in Mexico City and the corresponding attributable risks. MATERIAL AND METHODS Data was analyzed from a multicenter population-based case-control study conducted in Mexico City. RESULTS ORs for lung cancer in ever smokers were 6.2 (95% CI 3.9-10.2) for males and 2.8 (95% CI 1.7-4.4)...

BACKGROUND The facial colliculus is an elevated area that formed by fibers from the motor nucleus of 7`th cranial nerve as they loop over abducens nucleus. Clinical signs and symptoms lesions occur primarily due to injury nucleus, around paramedian pontine reticular formation, medial longitudinal fasciculus. etiology varies age. While tumors, demyelinating lesions, viral infections can be invol...

OBJECTIVES We tested the hypothesis that prostate-specific antigen (PSA) levels would be higher among prostate cancer deaths as compared with controls over time in the 25-year follow-up of the Multiple Risk Factor Intervention Trial of participants ages 35-57 at entry. METHODS The initial stored serum samples were collected in 1973-1975 and the mean length of follow-up to prostate cancer deat...

Introduction Drugs and other xenobiotics have effects that may vary greatly among individuals. Such variability in effect may be due to variability in either pharmacokinetics or pharmacodynamics. The major determinant of variability in pharmacokinetics is drug metabolism, which in many cases is due to polymorphisms in the genes for drug-metabolizing enzymes (1). This often results in subpopulat...

To address the complex nature of cancer occurrence and outcomes, approaches have been developed to simultaneously assess the role of two or more etiologic agents within hierarchical levels including the: (i) macroenvironment level (e.g., health care policy, neighborhood, or family structure); (ii) individual level (e.g., behaviors, carcinogenic exposures, socioeconomic factors, and psychologic ...

The establishment of a biorepository with linkage to clinical and epidemiologic data will provide an invaluable resource for cancer research, including studies of cancer etiology, progression, and prognosis, as well as development of biomarkers for early detection. Developing an infrastructure for a biorepository linked to clinical, pathologic, and epidemiologic data requires significant effort...

Objective(s): Polycystic ovary syndrome (PCOS) is an endocrinopathy in women, which, unlike its impact on fertility and health of women, there is no clear understanding about the causal mechanisms of this pathogenesis. The aim of this review paper is to investigate the pathophysiological pathways affecting the PCOS etiology, based on functions of gonadotropins– and steroid hormones–related gene...