Purpose: Fusion of the TMPRSS2 gene with the ERG oncogene and aberrant DNAmethylation patterns are commonly found in prostate cancer. The aim of this study was to analyze the relationship between ERG expression, DNA methylation of three biomarkers, and clinicopathologic features of prostate cancer. Experimental Design: Immunohistochemistry for ERG protein was conducted as a surrogate for TMPRSS...

What Is the mfERG? The electroretinogram (ERG) is a mass potential, the result of the summed electrical activity of the cells of the retina. Typically, the clinical ERG is elicited by full-field (Ganzfeld) flashes of light. With an appropriate selection of test and background lights, rod and cone function can be assessed separately. As the ganglion cells contribute relatively little to the full...

PURPOSE To determine the reliability of the Dawson, Trick, and Litzkow (DTL) electrode in electroretinographic recordings (ERG) in subjects of all ages, we evaluated ERG responses obtained with the contact lens (CL) and DTL electrodes and estimated a DTL/CL ratio for each sample. METHODS Seventy-nine volunteers aged 2-84 years (79 normal eyes) were recruited for the study. Electroretinographi...

Oncogenic activation of the ETS Related Gene (ERG) in humans was originally identified insubsets of Ewing sarcomas, myeloid leukemias and, recently, in the majority of prostatecancers. Expression of human ERG protein and consequently its functions in normal anddisease states needs to be better understood in light of its suggested role in cell differentiationand proliferation. He...

BACKGROUND Birth injuries are defined as the impairment of neonatal body function due to adverse events that occur at birth and can be avoidable or inevitable. Despite exact prenatal care, birth trauma usually occurs, particularly in long and difficult labor or fetal malpresentations. OBJECTIVES This study aimed to investigate the incidence of birth injuries and their related factors in Kasha...

BACKGROUND Physical activity in the elderly is influenced by aspects of aging that cause personal, mental, environmental, and social changes. Increases in factors that are barriers to activity cause physical energy expenditure to decrease. OBJECTIVES The aim of the present study was to survey the relationship between energy expenditure in metabolic equivalent units (MET) and factors that are ...

Background Different studies have been conducted to find the best adjuvant therapies for depression management. There are controversies over the effects of aspirin as an adjuvant therapy for depression. Objective To determine the effects of combined sertraline and aspirin therapy on depression severity among patients with major depressive disorder. Methods This randomized clinical trial was...

BACKGROUND Urban traffic accidents are an extensively significant problem in small and busy towns in Iran. This study tried to explore the epidemiological pattern of urban traffic accidents in Kashan and Aran-Bidgol cities, Iran. OBJECTIVES This study aimed to assess various epidemiological factors affecting victims of trauma admitted to a main trauma center in Iran. PATIENTS AND METHODS Du...

BACKGROUND Psoriasis is a common inflammatory papulosquamous disease of the skin with unknown aetiology that may be associated with the abnormal T-cell function. AIM This study was aimed to determine the prevalence of oral mucosal lesions and their associations with severity of psoriasis in psoriatic patients attending the dermatologic clinic of Shahid Beheshti Teaching Hospital at Kashan, Ir...

PURPOSE Fusion of the TMPRSS2 gene with the ERG oncogene and aberrant DNA methylation patterns are commonly found in prostate cancer. The aim of this study was to analyze the relationship between ERG expression, DNA methylation of three biomarkers, and clinicopathologic features of prostate cancer. EXPERIMENTAL DESIGN Immunohistochemistry for ERG protein was conducted as a surrogate for TMPRS...