A ketogenic diet is an important therapy used in the control of drug-refractory seizures. Many studies have shown that children and adolescents following ketogenic diets exhibit an over 50% reduction in seizure frequency, which is considered to be clinically relevant. These benefits are based on a diet containing high fat (approximately 90% fat) for 24 months. This dietary model was proposed in...

Many workers have demonstrated that extrahepatic tissues utilize ketone bodies in the absence of insulin (1). However, it has been postulated that a decrease in peripheral utilization of ketone bodies is a contributory factor in diabetic ketosis (2). No careful comparison of peripheral utilization by muscle from diabetic and nondiabetic preparations has been reported using modern techniques. Th...

ACETOACETIC and f-hydroxybutyric acids are known to undergo two chief metabolic changes, interconversion and oxidative breakdown. The reversibility of the reaction, acetoacetic acid =,-hydroxybutyric acid, was demonstrated in liver brei by Dakin & Wakeman [1910, 1, 2] and in perfused liver by Friedmann & Maase [1910]. Furthermore, the interconversion of these ketoand hydroxy-acids, both in live...

The circadian system has endowed animals with the ability to anticipate recurring food availability at particular times of day. As daily food anticipation (FA) is independent of the suprachiasmatic nuclei, the central pacemaker of the circadian system, questions arise of where FA signals originate and what role components of the circadian clock might play. Here we show that liver-specific delet...