نتایج جستجو برای: killed vaccines
تعداد نتایج: 69141 فیلتر نتایج به سال:
Collins, F. M. (University of Adelaide, Adelaide, South Australia), and Margaret Milne. Heat-labile antigens of Salmonella enteritidis. II. Mouse-protection studies. J. Bacteriol. 92:549-557. 1966.-A number of extracts prepared from a virulent and an avirulent strain of Salmonella enteritidis were used to immunize mice. Living and alcohol-killed whole-cell vaccines were also used to compare the...
BACKGROUND Killed whole-cell oral cholera vaccines (kOCVs) are becoming a standard cholera control and prevention tool. However, vaccine efficacy and direct effectiveness estimates have varied, with differences in study design, location, follow-up duration, and vaccine composition posing challenges for public health decision making. We did a systematic review and meta-analysis to generate avera...
Eurasian wild boar (Sus scrofa) is the main wildlife reservoir for tuberculosis (TB) in Iberia. This review summarizes the current knowledge on wild boar vaccination including aspects of bait design, delivery and field deployment success; wild boar response to vaccination with Bacillus Calmette-Guérin (BCG) and inactivated Mycobacterium bovis; and wild boar vaccination biosafety issues as well ...
Present laboratory tests for human typhoid vaccines use an intraperitoneal route of challenge given 7 days after injection of increasing doses of standard and test vaccines by the same route. In studies reported here, groups of B6D2 mice were vaccinated intraperitoneally with 2 x 10(8) acetone-killed Salmonella typhi Ty2, with the Vi antigen-free variant O-901, or with Yersinia enterocolitica a...
The prospect of developing an effective cholera vaccine has improved in recent years, with increased understanding of the mucosal immune system that protects against enteric infections and the discovery that volunteers recovering from cholera were substantially protected against reinfection for several years. The ideal vaccine would be cheap, safe, easy to administer, and effective after a sing...
For prevention of Streptococcus pneumoniae (pneumococcus) infections in infancy, protein-conjugated capsular polysaccharide vaccines provide serotype-specific, antibody-mediated immunity but do not cover all of the 90+ capsule serotypes. Therefore, microbiologists have sought protective noncapsular antigens common to all strains. Alternatively, we investigated killed cells of a noncapsulated st...
High titen of antibodies agaiast Anopheles gambiae midguts were produced in New Znaland rabbits to identiff midgut targets for an antimosquito vaccine. The serum from one of 8 rabbits (designated R2B6) killed 71.60lo (Abbott's adjusted % mortality\ of An. gambiaewithtnT days. Mosquitoes ingesting R2B6 serum were unable to absorb their blood meal nutrients, resulting in reduced oviposition and e...
Immunogenicity of a low-virulence vaccinal strain against Salmonella abortus-ovis infection in mice.
Strain Rv6, a streptomycin-independent reverse mutant of Salmonella abortus-ovis, multiplied and disseminated in vivo to a lesser extent than the virulent parental strain 15/5, as determined by subcutaneous inoculation of two outbred strains of mice with different susceptibilities to salmonella infection. This lower virulence of strain Rv6 was not modified by 10 passages in susceptible mice. Va...
The development of an efficient prophylactic HIV vaccine has been one of the major challenges in infectious disease research during the last three decades. Here, we present a mini review on strategies employed for the development of HIV vaccines with an emphasis on a well-established vaccine technology, the killed whole-virus vaccine approach. Recently, we reported an evaluation of the safety a...
The effect of prior opsonization of virulent Salmonella enteritidis on the growth of this organism in blood, liver, spleen, peritoneal cavity, and inguinal lymph node of specific pathogen-free mice prevaccinated with ethyl alcohol-killed S. enteritidis or living S. gallinarum was determined by daily enumeration. Both the vaccines and the challenge inocula were injected by the intravenous, intra...
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